Composition for preventing hair loss or enhancing hair growth comprising cyclophilin A

Abstract

The present invention relates to a composition for preventing hair loss or enhancing hair growth which comprises a cyclophilin A (CypA) protein, a nucleic acid having a nucleotide sequence encoding the CypA protein, or a CypA protein expression recombinant vector. The composition of the present invention is administered into skin cells to inhibit the IL-1 expression of the skin cells, to modulate the activities of ERK and c-jun, and to increase the expression of NF-kB p65, thereby promoting the growth and development of hair follicles. Therefore, the composition of the present invention can be useful in preventing hair loss or enhancing hair growth.

The invention claimed is: 
     
       1. A method for preventing hair loss or enhancing hair growth which comprises topically or subcutaneously administering a cyclophilin A (CypA) protein to a subject in need thereof. 
     
     
       2. The method of  claim 1 , wherein the CypA protein has the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2.