Methods for treating eye disorders using dipyridamole

Abstract

The present invention discloses methods for treating eye disorders. The methods include the step of administering an effective amount of a topically-administered dipyridamole. Preferably, the topically-administered dipyridamole is formulated as a solution. Preferably, the topically-administered dipyridamole is at least one agent selected from the group consisting of: dipyridamole, and a pharmaceutically-acceptable salt thereof. Preferably, the effective amount corresponds to a concentration of at least about 10 −5 molarity. Preferably, the effective amount is based on a treatment administration of at least once every other day.

What is claimed is:  
     
       1. A method comprising the step of:
 administering an effective amount of a topical dipyridamole composition for treating eye disorders affecting the lacrimal system of the eye to a subject in need thereof due to a lacrimal system eye disorder selected from the group consisting of dry eye, xerophthalmia and Sjogren's syndrome. 
 
     
     
       2. A method comprising:
 (a) identifying a subject in need of treatment for a lacrimal system eye disorder selected from the group consisting of dry eye, xerophthalmia and Sjogren's syndrome; and 
 (b) topically administering an effective amount of a dipyridamole to said subject to treat said eye disorder. 
 
     
     
       3. A method according to  claim 2 , wherein said effective amount of dipyridamole is provided in a form selected from the group consisting of an aqueous solution, a cream and an ointment. 
     
     
       4. A method according to  claim 3 , wherein said effective amount of dipyridamole is provided as an aqueous solution with a pH ≦6.7. 
     
     
       5. A method according to  claim 2 , wherein said administering comprises:
 administering the effective amount of dipyridamole at a treatment frequency until symptoms abate; and 
 administering the effective amount of dipyridamole at a maintenance frequency thereafter; 
 wherein said maintenance frequency is lower than said treatment frequency. 
 
     
     
       6. A method according to  claim 2 , comprising increasing the concentration of dipyridamole according to tolerance of said subject. 
     
     
       7. A method according to  claim 2 , wherein dipyridamole is the sole active ingredient administered. 
     
     
       8. A method according to  claim 1 , wherein dipyridamole is the sole active ingredient in said composition.