N-substituted nicotinamide compounds and compositions for the treatment migraine and neurologic diseases

Abstract

The invention relates to N-substituted nicotinamide compounds of Formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of Formula I, and methods for the treatment of migraine and neurologic diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of epilepsy, migraine, Post Herpetic Neuralgia, Acute and Chronic Pain, Alzheimer's disease, Creutzfeld Disease, familial amyloid polyneuropathy, parkinson's disease, fibromyalgia syndrome.

The invention claimed is: 
     
       1. A compound of Formula I: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt, hydrate, solvate, enantiomer, or stereoisomer thereof, wherein: 
         R 1  represents 
       
       
         
           
           
               
               
           
         
         R 2  represents NULL, 
       
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         R 3  represents 
       
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         each n is independently 1, 2, 3, 4 or 5; 
         each a is independently 2, 3 or 7; 
         each b is independently 3, 5 or 6; 
         each e is independently 1, 2 or 6; and 
         each c and each d are each independently H, D, —OH, —OD, C 1 -C 6 -alkyl, —NH 2  or —COCH 3 . 
       
     
     
       2. A pharmaceutical composition comprising a compound of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
       3. The pharmaceutical composition of  claim 2 , wherein said pharmaceutical composition is formulated for delivery to a subject by oral administration, delayed release or sustained release, transmucosal, syrup, topical, parenteral administration, injection, subdermal, oral solution, rectal administration, buccal administration or transdermal administration.