US9149458B1ActiveUtility

Method for treating hypertriglyceridemia with a Wedelia chinensis extract

31
Assignee: WYNTEK CORPPriority: Feb 3, 2015Filed: Feb 3, 2015Granted: Oct 6, 2015
Est. expiryFeb 3, 2035(~8.5 yrs left)· nominal 20-yr term from priority
Inventors:Tseng-Rong TuWen-Mai HsuEugene Fan
A61P 43/00A61P 3/10A61P 9/10A61P 39/00A61P 3/06A61P 5/14A61P 3/04A61P 13/12A61K 31/37A61K 31/353A61K 36/28A61K 31/366A61K 31/352
31
PatentIndex Score
0
Cited by
16
References
22
Claims

Abstract

A method for treating hypertriglyceridemia with a composition containing wedelolactone, luteolin, and apigenin. Also provided is a method for reducing the risk of developing hypertriglyceridemia by administering the composition to a subject at risk thereof. The composition can be an extract of Wedelia chinensis.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A method for treating hypertriglyceridemia, the method comprising identifying a subject having hypertriglyceridemia and administering to the subject an effective amount of a composition containing wedelolactone, luteolin, and apigenin. 
     
     
       2. The method of  claim 1 , wherein the hypertriglyceridemia results from alcoholism, diabetes, obesity, metabolic syndrome, hypothyroidism, nephrotic syndrome, or a combination thereof. 
     
     
       3. The method of  claim 1 , wherein the hypertriglyceridemia results from a drug treatment. 
     
     
       4. The method of  claim 3 , wherein the drug is selected from the group consisting of a thiazide diuretic, a beta-adrenergic blocking agent, oral estrogen, tamoxifen, a glucocorticoid, oral isotretinoin, and an anti-retroviral agent. 
     
     
       5. The method of  claim 1 , wherein the subject has a lipoprotein lipase deficiency or an apolipoprotein C-II deficiency. 
     
     
       6. The method of  claim 1 , wherein the subject has familial hyperlipidemia or familial hypertriglyceridemia. 
     
     
       7. The method of  claim 1 , wherein the composition is an acidic aqueous extract or an ethanolic extract of  Wedelia chinensis.    
     
     
       8. The method of  claim 2 , wherein the composition is an acidic aqueous extract or an ethanolic extract of  Wedelia chinensis.    
     
     
       9. The method of  claim 3 , wherein the composition is an acidic aqueous extract or an ethanolic extract of  Wedelia chinensis.    
     
     
       10. The method of  claim 4 , wherein the composition is an acidic aqueous extract or an ethanolic extract of  Wedelia chinensis.    
     
     
       11. The method of  claim 5 , wherein the composition is an acidic aqueous extract or an ethanolic extract of  Wedelia chinensis.    
     
     
       12. The method of  claim 6 , wherein the composition is an acidic aqueous extract or an ethanolic extract of  Wedelia chinensis.    
     
     
       13. A method for reducing the risk of developing hypertriglyceridemia, the method comprising identifying a subject at risk of developing hypertriglyceridemia and administering to the subject an effective amount of a composition containing wedelolactone, luteolin, and apigenin. 
     
     
       14. The method of  claim 13 , wherein the subject suffers from alcoholism, diabetes, obesity, metabolic syndrome, hypothyroidism, nephrotic syndrome, or a combination thereof. 
     
     
       15. The method of  claim 13 , wherein the subject has a diet with a positive energy-intake balance and a high fat or high glycemic index. 
     
     
       16. The method of  claim 13 , wherein the subject suffers from stress, is physically inactive, or smokes. 
     
     
       17. The method of  claim 13 , wherein the subject has a family history of coronary heart disease. 
     
     
       18. The method of  claim 13 , wherein the composition is an acidic aqueous extract or an ethanolic extract of  Wedelia chinensis.    
     
     
       19. The method of  claim 14 , wherein the composition is an acidic aqueous extract or an ethanolic extract of  Wedelia chinensis.    
     
     
       20. The method of  claim 15 , wherein the composition is an acidic aqueous extract or an ethanolic extract of  Wedelia chinensis.    
     
     
       21. The method of  claim 16 , wherein the composition is an acidic aqueous extract or an ethanolic extract of  Wedelia chinensis.    
     
     
       22. The method of  claim 17 , wherein the composition is an acidic aqueous extract or an ethanolic extract of  Wedelia chinensis.

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