Complex combining an organic silicon derivative with hyaluronic and acid calibrated fragments, for preventive and repairing action of cutaneous damages

Abstract

The invention concerns a complex based on an organic silicon derivative. The invention is characterized in that said derivative is combined, by weak bonds, with one or several hyaluronic acid calibrated fragments of molecular weight comprised between 150 and 750 kDa, said derivative being of general formula (I): R x Si(OH) 4-x , (I) wherein: R is a (C 1 -C 4 )alkyl, and x=1 or 2. The invention also concerns the use of such a complex in the prevention or the repair of cutaneous damages.

What is claimed is: 
     
       1. A method of cosmetic care for repairing skin aging damage to a patient in need of boosting epidermal cell activity and limiting pro-inflammatory adverse effect of hyaluronic acid fragments produced by catabolic action of cutaneous tissue, the method comprising
 applying on a skin, a complex based on:
 an organic silicon derivative combined with 
 one or several hyaluronic acid calibrated fragments of molecular weight between 150 and 600 kDa, 
 said derivative being of formula (1):
   R x Si(OH) 4-x   (I),
 
 
 wherein R is a (C 1 -C 4 )alkyl, and x=1 or 2. 
 
 
     
     
       2. The method according to  claim 1 , wherein said organic silicon derivative of formula (I) is selected from the group consisting of monomethylsilanetriol and dimethylsilanediol. 
     
     
       3. The method according to  claim 1 , wherein monomethylsilanetriol is combined with the one or several hyaluronic acid fragments of molecular weight between 150 and 600 kDa. 
     
     
       4. A method of cosmetic care for repairing skin aging damage to a patient in need of boosting the epidermal cell activity and limiting the pro-inflammatory adverse effect of hyaluronic acid fragments produced by catabolic action of cutaneous tissue, the method comprising applying on a skin, a composition comprising:
 i) a complex based on:
 an organic silicon derivative combined with 
 one or several hyaluronic acid calibrated fragments of molecular weight between 150 and 600 kDa, 
 
 said derivative being of formula (I):
   R x Si(OH) 4-x   (I)
 
 
 wherein R is a (C 1 -C 4 )alkyl, and x=1 or 2, and 
 ii) a physiologically compatible excipient with skin. 
 
     
     
       5. The method according to  claim 4 , wherein the concentration of said complex in the composition is between 2% and 5% in weight in relation to the total weight of the composition. 
     
     
       6. The method according to  claim 4 , wherein said physiologically compatible excipient with skin is selected from the group consisting of a preservative, a body fat, a dye, an emulsifier, a gelling agent, an emollient, a moisturizer, a pigment, and an antioxidant. 
     
     
       7. The method according to  claim 6 , wherein said physiologically compatible excipient with skin is selected from the group consisting of hydrogenated polyisobutene, isobutyl myristate, cetyl palmitate, ethylene glycol monostearate, sorbitan laurate, polysorbate 20, carbomer, phenoxyethanol, sodium benzoate, sorbic acid, 1,3-butanediol, glycerine, and sodium carbonate. 
     
     
       8. The method according to  claim 4 , wherein said composition is formulated in a form selected from the group consisting of a cream, a milk, a gel, a lotion, and an emulsion.