Dosing regimens and methods of treatment using carbon monoxide

Abstract

The present invention is directed to dosing regimens for the administration of carbon monoxide in the treatment of various indications as well as methods for enhancing organ function following transplant thereof.

The invention claimed is: 
     
       1. A method for treating a patient in need thereof with carbon monoxide, comprising administering to the patient an effective amount of carbon monoxide that results in a carboxyhemoglobin concentration of between about 3% and about 15% without negative impact on cardiovascular and neurocognitive functions of the patient wherein carbon monoxide is administered via inhalation to the patient intra-operatively during organ transplant surgery, wherein the organ is kidney, in a single dose ranging between about 0.7 mg/kg to about 3 mg/kg for 1 hr. 
     
     
       2. The method of  claim 1 , wherein the patient is administered carbon monoxide at a dose ranging between about 2 mg/kg to about 3 mg/kg for 1 hr. 
     
     
       3. The method of  claim 1 , wherein the patient is administered carbon monoxide at a dose of 3 mg/kg for 1 hr. 
     
     
       4. The method of  claim 1 , further comprising administering an additional agent that has a therapeutic effect wherein the additional agent is a hemeoxygenase-1 or hemeoxygenase-1-affecting additional agent. 
     
     
       5. The method of  claim 1 , wherein carbon monoxide is administered to the patient in a gaseous form.