US8728512B2ExpiredUtilityA1

Treatment and composition for wound healing

65
Assignee: JACKSON CHRISTOPHER JOHNPriority: Jun 13, 2001Filed: Jul 17, 2009Granted: May 20, 2014
Est. expiryJun 13, 2021(expired)· nominal 20-yr term from priority
Inventors:Christopher J. JacksonPhilip Neil Sambrook
A61P 9/10A61P 43/00A61P 29/00A61P 17/02A61P 19/08A61K 38/4866A61P 19/04A61K 9/0048
65
PatentIndex Score
2
Cited by
34
References
11
Claims

Abstract

A method and medicament for promoting wound healing in a subject is disclosed. The medicament comprises an effective amount of an agent comprising one or more of; (i) an activated protein C (APC), (ii) a functional fragment of an APC, (iii) an APC mimetic compound, and (iv) protein C. Delivery systems including gels, sponges, gauzes and meshes incorporating the agent for topical administration are also described.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A method for promoting wound healing in a subject, said method comprising topically administering to said subject an effective amount of an agent comprising an activated protein C (APC), optionally in admixture with a pharmaceutically-acceptable carrier, wherein the wound is selected from the group consisting of dermal ulcers, burns, oral wounds, bone and cartilage damage, and warfarin-related skin necrosis. 
     
     
       2. The method of  claim 1 , wherein the agent is human APC. 
     
     
       3. The method of  claim 1 , wherein the agent is administered to said subject within 1 to 10 hours of wounding. 
     
     
       4. The method of  claim 1 , wherein the wound for which wound healing is to be promoted is a dermal ulcer. 
     
     
       5. The method of  claim 1 , wherein the effective amount of the agent is in the range of 0.1 to 1000 μg per kg of body weight. 
     
     
       6. The method of  claim 5 , wherein the effective amount of the agent is in the range of 0.1 to 10 μg per kg of body weight. 
     
     
       7. The method of  claim 1 , wherein the wound for which wound healing is promoted is an epithelial wound. 
     
     
       8. The method of  claim 1 , wherein the wound for which wound healing is to be promoted is a burn. 
     
     
       9. The method of  claim 1 , wherein the wound for which wound healing is to be promoted is an oral wound. 
     
     
       10. The method of  claim 1 , wherein the wound for which wound healing is to be promoted is bone and cartilage damage. 
     
     
       11. The method of  claim 1 , wherein the wound for which wound healing is to be promoted is a warfarin-related skin necrosis.

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