Agent for expelling parasites in humans, animals or birds

Abstract

This invention relates to an agent which may be used to expel parasites from humans, mammals or birds. The agent of the invention may a vegetable product, Ferula Assafoetida , which is very effective in expelling parasites.

What is claimed is: 
     
       1. A method for expelling helminthes resistant to a chemical anthelminthic in an animal in need thereof, comprising the steps of:
 determining whether the animal is infected with a helminth that is resistant to a chemical anthelminthic; and 
 administering a composition comprising a therapeutically effective amount of asafoetida obtained from  Ferula asafoetida  to said animal in need thereof. 
 
     
     
       2. The method according to  claim 1 , wherein the helminth are resistant to imidothiazole, benzimidazole and macrocyclic lactones. 
     
     
       3. The method according to  claim 1 , wherein the helminth are resistant to thiabendazole, mebendazole, fenbendazole, oxibendazole, oxfendazole, febantel, albendazole, ivermectin, abamectin, doramectin, eprinomectin, moxidectin, levamisole, netobimin, morantel, diethylcarbamazine, niclosamide, praziquantel, pyrantel pamoate, piperazine citrate, flubendazole, piperazine adipate, milbemycin oxime, imidacloprid, emodepside, closantel or levamisole hydrochloride. 
     
     
       4. The method according to  claim 1 , wherein said animal is a human, mammal or bird. 
     
     
       5. The method of  claim 4 , wherein the mammal are selected form the group consisting of Bovinae,  Ovis , Capra, Suidae, Canis, Filinae, Equus, Leporidae, Cricetidae and  Caviidae Cavia.    
     
     
       6. The method of  claim 4 , wherein the mammal are selected form the group consisting of Bovinae  Bos, Ovis aries , Capra  aegagrus hircus , suinae  sus , Canis  lupus familiaris, Felis catus , Equus  ferus caballus, Oryctolagus cuniculus  and  Cricetus cricetus.    
     
     
       7. The method of  claim 4 , wherein the bird belong to Ava. 
     
     
       8. The method of  claim 4 , wherein the bird are selected from the group consisting of poultry, Columbidae, exotic birds, cage-birds, pheasants, quails, tragopans, partridges, peacocks, guinea fowl and francolins. 
     
     
       9. The method of  claim 4 , wherein the bird are selected from the group consisting of  Psittaciformes, Serinus canaria  and Fringillidae. 
     
     
       10. The method of  claim 1 , wherein the helminth are selected from the group consisting tapeworms, roundworms, mine worms, gastrointestinal nematodes, lungworms, flatworms, trematodes, arthropods larvae, liver fluke or coccidian. 
     
     
       11. The method of  claim 1 , wherein the helminth occur in Equus and are selected from the group consisting of  Anaplocephala perfoliata, Anaplocephala  spp.,  Ascaris  spp.,  Cilicodontophorus bicornatus, Cilicodontophorus  spp.,  Cilicostephanus asymetricus, Cilicostephanus bidentatus, Cilicostephanus calicatus, Cilicostephanus goldi, Cilicostephanus longibursatus, Cilicostephanus minutes, Cilicostephanus  spp.,  Coronocyclus coronatus, Coronocyclus labiatus, Coronocyclus labratus, Coronocyclus  spp.,  Craterostomum acuticaudatum, Craterostomum  spp.,  Cyathostomum catinatum, Cyathostomum pateratum, Cyathostomum  spp.,  Cylicocereus spp., Cylicocyclus ashworthi, Cylicocyclus brevicapsulatus, Cylicocyclus elongates, Cylicocyclus insigne, Cylicocyclus leptostomum, Cylicocyclus nassatus, Cylicocyclus radiates, Cylicocyclus  spp.,  Cylicocyclus ultrajentinus, Cylicodontophorus bicoronatus, Cylicodontophorus  spp.,  Cylicostephanus  spp.,  Dictyocaulus arnfieldi, Dictyocaulus  spp.,  Fasciola hepatica/gigantic, Gasterophilus intestinalis, Gasterophilus nasalis, Gasterophilus  spp.,  Gyalocephalus capitatus, Gyalocephalus  spp.,  Habronema muscae, Habronema  spp.,  Onchocerca  spp.,  Onchocerca cervicalis, Oxyuris equi, Oxyuris  spp.,  Paranoplocephala mamillana, Paranoplocephala  spp.,  Parapoteriostomum mettami, Parapoteriostomum  spp.,  Parascaris equorum, Parascaris viviparum, Parascaris  spp.,  Petrovinema poculatus, Petrovinema  spp.,  Poteriostomum imparidentatum, Poteriostomum  spp.,  Strongylus edentates, Strongyloides westeri, Strongylus craterostomum, Strongyloides  spp.,  Strongylus edentatus, Strongylus equinus, Strongylus  spp.,  Strongylus triodontophorus, Strongylus vulgaris, Trichonema  spp.,  Trichostrongylus axei, Trichostrongylus  spp.,  Triodontophorus brevicauda, Triodontophorus serratus, Triodontophorus  spp.,  Triodontophorus tenuicollis, Paramphistomum  spp.,  Paramphistomum cervi, Taenia  spp,  Taenia saginata, Baylisascars  spp,  Baylisascaris procyonis, Nematodirus  spp.,  Nematordirus battus, Nematodirus helvetianus, Teladorsagia  spp and  Teladorsagia circumcincta.    
     
     
       12. The method of  claim 1 , wherein the helminth occur in Filinae and are selected from the group consisting of  Ancylostoma caninum, Ancylostoma  spp.,  Ancylostoma tubaeforme, Dipylidium caninum, Dipylidium  spp.,  Dirofilaria imitis, Dirofilaria  spp.,  Echinococcus multilocularis, Echinococcus  spp.,  Fasciola hepatica/gigantic, Hydatigera taeniaeformis, Hydatigera  spp.,  Joyeuxiella pasqualei, Joyeuxiella  spp.,  Mesocestoides  spp.,  Multiceps multiceps, Multiceps  spp.,  Taenia pisiformis, Taenia  spp.,  Taenia taeniaformis, Toxocara canis, Toxocara cati, Toxascaris leonina, Toxocara  spp.,  Trichuris vulpis, Trichuris  spp.,  Uncinaria  spp.,  Uncinaria stenocephala, Paramphistomum  spp.,  Paramphistomum cervi, Taenia  spp,  Taenia saginata, Baylisascars  spp,  Baylisascaris procyonis, Nematodirus  spp.,  Nematordirus battus, Nematodirus helvetianus, Teladorsagia  spp and  Teladorsagia circumcincta.    
     
     
       13. The method of  claim 1 , wherein the helminth occur in Canis and are selected from the group consisting of  Ancylostoma braziliense, Ancylostoma caninum, Ancylostoma  spp.,  Ancylostoma tubaeforme, Dipylidium caninum, Dipylidium  spp.,  Echinococcus granulosus, Echinococcus  spp.,  Fasciola hepatica/gigantic, Giardia  spp.,  Joyeuxiella pasqualei, Joyeuxiella  spp.,  Mesocestoides  spp.,  Multiceps multiceps, Multiceps  spp.,  Strongyloides  spp.,  Taenia hydatigena, Taenia ovis, Taenia pisiformis, Taenia  spp.,  Toxocara canis, Toxocara cati, Toxocara  spp.,  Toxascaris leonina, Toxascaris  spp.,  Trichuris vulpis, Trichuris  spp.,  Uncinaria  spp,  Uncinaria stenocephala, Paramphistomum  spp.,  Paramphistomum cervi, Taenia  spp,  Taenia saginata, Baylisascars  spp,  Baylisascaris procyonis, Nematodirus  spp.,  Nematordirus battus, Nematodirus helvetianus, Teladorsagia  spp and  Teladorsagia circumcincta.    
     
     
       14. The method of  claim 1 , wherein the helminth occur in Bovinae and are selected from the group consisting of  Bunostomum phlebotomum, Bunostomum  spp.,  Capillaria spp., Chabertia  spp.,  Chrysoma bezzania, Chrysoma  spp.,  Cooperia oncophora, Cooperia pectinata, Cooperia punctata, Cooperia  spp.,  Cooperia surnababa, Dictiocaulus  spp.,  Dictiocaulus viviparous, Fasciola hepatica/gigantic, Haemonchus placei, Haemonchus  spp.,  Hypoderma bovis, Hypoderma lineatum, Hypoderma  spp.,  Mecistocirrus digitatus, Mecistocirrus  spp.,  Moniezia  spp.,  Nematodirus helvetiana, Nematodirus spathiger, Nematodirus  spp.,  Oesophagostomum radiatum, Oesophagostomum  spp.,  Oesophagostomum venulosum, Ostertagia lyrata, Ostertagia ostertagi, Ostertagia  spp.,  Parafilaria  spp.,  Strongyloides papillosus, Strongyloides  spp.,  Thelazia  spp.,  Toxocara vitulorum, Toxocara  spp.,  Trichostrongylus axei, Trichostrongylus colubriformis, Trichostrongylus  spp.,  Trichostrongylus vitrines, Trichuris  spp,  Paramphistomum  spp.,  Paramphistomum cervi, Taenia  spp,  Taenia saginata, Baylisascars  spp,  Baylisascaris procyonis, Nematodirus  spp.,  Nematordirus battus, Nematodirus helvetianus, Teladorsagia  spp and  Teladorsagia circumcincta.    
     
     
       15. The method of  claim 1 , wherein the helminth occur in Capra or  Ovis  and are selected from the group consisting of  Bunostomum phlebotomum, Bunostomum  spp.,  Capillaria  spp.,  Cestodes  (tapeworm),  Chabertia ovina, Chabertia  spp.,  Cooperia curtecei, Cooperia  spp.,  Dictiocaulus filarial, Dictiocaulus  spp.,  Fasciola hepatica/gigantic, Gaigeria pachyscelis, Gaigeria  spp.,  Haemonchus contortus, Haemonchus  spp.,  Moniezia spp., Nematodirus fillicollis, Nematodirus spathiger, Nematodirus  spp.,  Oesophagostomum columbianum, Oesophagostomum  spp.,  Oesophagostomum venulosum, Oestrus ovis, Oestrus  spp.,  Ostertagia circumcincta, Ostertagia  spp.,  Ostertagia trifurcate, Protostrongylus refuscens, Protostrongylus  spp.,  Strongyloides papillosus, Strongyloides  spp.,  Trichostrongylus axei, Trichostrongylus colubriformis, Trichostrongylus  spp.,  Trichostrongylus vitrinus, Trichuris ovis, Trichuris  spp,  Paramphistomum  spp.,  Paramphistomum cervi, Taenia  spp,  Taenia saginata, Baylisascars  spp,  Baylisascaris procyonis, Nematodirus  spp.,  Nematordirus battus, Nematodirus helvetianus, Teladorsagia  spp and  Teladorsagia circumcincta.    
     
     
       16. The method of  claim 1 , wherein the helminth occur in Suidae and are selected from the group consisting of  Ascaris suum, Isospora suis, Ascaris  spp.,  Fasciola hepatica/gigantic, Hyostrongylus rubidus, Hyostrongylus  spp.,  Metastrongylus  spp.,  Oesophagostomum  spp.,  Stephanuris dentatus, Stephanuris  spp.,  Strongyloides ransomi, Strongyloides  spp.,  Trichuris suis, Trichuris  spp,  Paramphistomum  spp.,  Paramphistomum cervi, Taenia  spp,  Taenia saginata, Baylisascars  spp,  Baylisascaris procyonis, Nematodirus  spp.,  Nematordirus battus, Nematodirus helvetianus, Teladorsagia  spp and  Teladorsagia circumcincta.    
     
     
       17. The method of  claim 1 , wherein the helminth occur in humans and are selected from the group consisting of  Ascaris lumbricoides, Ascaris  spp.,  Ancylostoma duodenale, Echinococcus  spp.,  Brugia  spp.,  Clonorchis  spp.,  Diphyllobothrium latum, Diphyllobothrium  spp.,  Enterobius vermicularis, Enterobius  spp.,  Echinococcus granulosus, Echinocuccus mulitcularis, Echinococcus  spp.,  Fasciolopsis buski, Fasciolopsis  spp.,  Hymenolepsis nana, Hymenolepsis  spp.,  Necator americanus, Necator  spp.,  Schistosoma haematobium, Schistosoma mansoni, Schistosoma japonicum, Schistosoma  spp.,  Strongyloides stercoralis, Strongyloides  spp.,  Taenia saginata, Taenia solium, Taenia  spp.,  Toxocara canis, Toxocara cati, Toxocara  spp.,  Trichuris trichiura, Trichuris  spp.,  Trichinella spiralis, Trichinella  spp.,  Wucheria  spp. and  Fasciola hepatica/gigantic.    
     
     
       18. The method of  claim 1 , wherein the helminth occur in Ava and are selected from the group consisting of  Amidostomum anseris, Amidostomum  spp.,  Ascaridia columbae, Ascaridia galli, Ascaridia  spp.,  Capillaria  spp.,  Heterakis gallinarum, Heterakis  spp.,  Raillietina  spp.,  Syngamus trachea, Syngamus  spp.,  Trichostrongylus  spp. and  Trichostrongylus tenuis.    
     
     
       19. The method of  claim 1 , wherein said composition comprising asafetida further comprise an additional active ingredient for expelling the helminth. 
     
     
       20. The method of  claim 1 , wherein said composition is in the form of an animal feed. 
     
     
       21. The method of  claim 1 , wherein said composition is in a form suitable for intravenous administration; a suppository; a paste; a powder; a pill; a form suitable for enteral administration or a form suitable for transdermal administration. 
     
     
       22. The method of  claim 1 , wherein said composition in the form of a spray, lotion, solution, or other form suitable for topical use. 
     
     
       23. The method of  claim 1 , wherein said asafoetida is administered at a dose of between 0.001 g to 0.1 g/kg body weight. 
     
     
       24. The method of  claim 1 , wherein said asafoetida is administered at a dose of between about 0.05 g to about 0.07 g/kg body weight. 
     
     
       25. The method of  claim 1 , wherein said asafoetida is administered at a dose of about 0.06 g/kg body weight.