US7989499B2ExpiredUtilityA1

Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase

69
Assignee: MITOTEK LLCPriority: Feb 9, 2005Filed: Feb 8, 2006Granted: Aug 2, 2011
Est. expiryFeb 9, 2025(expired)· nominal 20-yr term from priority
Inventors:Paul Q. Anziano
A61P 43/00A61P 9/00A61P 9/04C07C 235/34A61P 25/30A61P 25/28C07C 235/32
69
PatentIndex Score
2
Cited by
85
References
2
Claims

Abstract

The present invention is directed to methods of modulating the activity of an isoform of manganese superoxide dismutase which is useful for the treatment of diseases such as neurodegenerative diseases and heart failure.

Claims

exact text as granted — not AI-modified
1. A method of inhibiting an activity of isoMnSOD in a cell comprising contacting the cell with a compound or pharmaceutically acceptable salt or prodrug thereof, wherein the compound is 2-(3,4-dihydroxy-phenyl)-N-heptadec-8-enyl-acetamide or (2-(2,5-dihydroxy-phenyl)-N-heptadec-8-enyl-acetamide). 
     
     
       2. The method of  claim 1  wherein the activity is pro-oxidant activity.

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