Antimicrobial compounds

Abstract

The invention relates to compositions comprising a compound based on the general formula (I) R 1 -Arg-R 2 —NH—CH(R 3 )—CH 2 —NH—R 4   (I) and a carrier, diluent or an excipient.

1. A composition comprising
 a) a compound selected from the group consisting of 
 
       
         
           
           
               
               
           
         
          and 
         b) a carrier, diluent or an excipient; wherein the composition is effective against a disease or a mixture of diseases caused by microorganisms selected from the group consisting of  Staphylococci, Pneumococci, Streptococci, Listeria, Candida  and  Aspergillus.    
       
     
     
       2. The composition according to  claim 1 , wherein the  Staphylococci, Pneumococci, Streptococci  or  Listeria  comprises a resistant or multiresistant bacteria. 
     
     
       3. The composition according to  claim 1 , further comprising one or more therapeutic agents. 
     
     
       4. The composition according to  claim 3 , wherein the therapeutic agents are selected from the group consisting of penicillins, cephalosporins, carbacephems, cephamycins, carbapenems, monobactams, aminoglycosides, glycopeptides, quinolones, tetracyclines, macrolides, fluoroquinolones, antiseptic agents, biguanides, docosanol, acetic acid, and hydrogen peroxide. 
     
     
       5. The composition according to  claim 1 , wherein the composition is in the form selected from the group consisting of granules, powders, tablets, coated tablets, (micro) capsules, suppositories, syrups, emulsions, gels, ointments, suspensions, creams, aerosols, injectable solutions in ampule form, and drops. 
     
     
       6. A method of treating a mammal having a microbial infection or disease comprising administration of an effective amount of the composition according to  claim 1 , wherein said microbial infection or disease is caused by microorganisms selected from the group consisting of  Staphylococci, Pneumococci, Streptococci, Listeria, Candida  and  Aspergillus.