Antibodies to HHPEN62 polypeptide

Abstract

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

1. An isolated antibody or fragment thereof that specifically binds to a polypeptide selected from the group consisting of:
 (a) a polypeptide whose amino acid sequence consists of amino acid residues 1 to 508 of SEQ ID NO:139; 
 (b) a polypeptide whose amino acid sequence consists of a portion of SEQ ID NO:139, wherein said portion is at least 30 contiguous amino acid residues of SEQ ID NO:139; and 
 (c) a polypeptide whose amino acid sequence consists of a portion of SEQ ID NO:139, wherein said portion is at least 50 contiguous amino acid residues of SEQ ID NO:139. 
 
     
     
       2. The antibody or fragment thereof of  claim 1  that specifically binds polypeptide (a). 
     
     
       3. The antibody or fragment thereof of  claim 1  that specifically binds polypeptide (b). 
     
     
       4. The antibody or fragment thereof of  claim 1  that specifically binds polypeptide (c). 
     
     
       5. The antibody or fragment thereof of  claim 3  that specifically binds a polypeptide whose amino acid sequence consists of amino acid residues 1 to 508 of SEQ ID NO:139. 
     
     
       6. The antibody or fragment thereof of  claim 1 , which is a polyclonal antibody. 
     
     
       7. The antibody or fragment thereof of  claim 1 , which is a monoclonal antibody. 
     
     
       8. The antibody or fragment thereof of  claim 1 , which is selected from the group consisting of:
 (a) a chimeric antibody; 
 (b) a human antibody; 
 (c) a humanized antibody; 
 (d) a single chain antibody; and 
 (e) a Fab fragment. 
 
     
     
       9. The antibody or fragment thereof of  claim 1 , which is labeled. 
     
     
       10. The antibody or fragment thereof of  claim 1  wherein said polypeptide bound by said antibody or fragment thereof is glycosylated. 
     
     
       11. The antibody or fragment thereof of  claim 1  wherein said antibody or fragment thereof specifically binds to said polypeptide in a Western blot. 
     
     
       12. The antibody or fragment thereof of  claim 1  wherein said antibody or fragment thereof specifically binds to said polypeptide in an ELISA. 
     
     
       13. An isolated cell that produces the antibody or fragment thereof of  claim 1 . 
     
     
       14. A hybridoma that produces the antibody or fragment thereof of  claim 1 . 
     
     
       15. The antibody or fragment thereof of  claim 2 , which is a polyclonal antibody. 
     
     
       16. The antibody or fragment thereof of  claim 2 , which is a monoclonal antibody. 
     
     
       17. The antibody or fragment thereof of  claim 2  which is selected from the group consisting of:
 (a) a chimeric antibody; 
 (b) a human antibody; 
 (c) a humanized antibody; 
 (d) a single chain antibody; and 
 (e) a Fab fragment. 
 
     
     
       18. The antibody or fragment thereof of  claim 2 , which is labeled. 
     
     
       19. The antibody or fragment thereof of  claim 2  wherein said polypeptide bound by said antibody or fragment thereof is glycosylated. 
     
     
       20. The antibody or fragment thereof of  claim 2  wherein said antibody or fragment thereof specifically binds to said polypeptide in a Western blot. 
     
     
       21. The antibody or fragment thereof of  claim 2  wherein said antibody or fragment thereof specifically binds to said polypeptide in an ELISA. 
     
     
       22. An isolated cell that produces the antibody or fragment thereof of  claim 2 . 
     
     
       23. A hybridoma that produces the antibody or fragment thereof of  claim 2 . 
     
     
       24. A method of detecting a polypeptide comprising amino acid residues 1 to 508 of SEQ ID NO:139 in a biological sample comprising:
 (a) contacting the biological sample with the antibody or fragment thereof of  claim 1 ; 
 (b) allowing a complex to form between said polypeptide comprising amino acid residues 1 to 508 of SEQ ID NO:139 and said antibody of  claim 1 ; and, 
 (c) detecting said complex.