Sensor controlled analysis and therapeutic delivery system

Abstract

A method and apparatus for non-invasively withdrawing and accurately evaluating analytes quickly, painlessly and reliably from a biological subject automatically and controlling subsequent administration of therapeutic agents in response to such analyte sample analysis. Improvements are provided in electro-osmotic sample withdrawal, dosimetry and iontophoretic delivery subsystems, biosensors electrode construction and arrangement, intervenors, mediators, bolus delivery, and related subsystems.

1. In a compact patch adapted to be worn by a biological subject, the combination comprising:
 first means within said patch for electro-osmotic withdrawal of fluid samples; 
 second biosensor means within the same said patch for evaluation of said samples; and 
 third means within the same said patch for providing iontophoretic treatment to a biological subject in response to said biosensor means whereby said compact patch is provided including said first, second and third means in an integral package.