Aryloxy propanolamines for improving livestock production

Abstract

Disclosed is a compound represented by structural formula (I): R1 is a substituted or unsubstituted aryl group. R2 and R3 are independently —H, a C1-C4 straight chained or branched alkyl group. R4 and R5 are independently —H, a C1-C4 straight chained or branched alkyl group or, taken together with the nitrogen atom to which each is bonded, a non-aromatic heterocyclic ring. Ring A and Ring B are independently further substituted with zero, one or two substituents. Physiologically acceptable salts of structural formula shown above are also included. Also disclosed is a method promoting growth, efficiency of feed utilization and/or production of lean body mass in a livestock animal. The method comprises administering to the animal an effective amount of one or more compounds represented by the structural formula as shown or a physiologically acceptable salt thereof.

1. A compound represented by the following structural formula: 
                 
 
       or a physiologically acceptable salt thereof, wherein R1 is represented by a structural formula selected from the group consisting of: 
                 
 
     
     
       2. A compound represented by the following structural formula: 
                 
 
       or a physiologically acceptable salt thereof. 
     
     
       3. The ammonium chloride, ammonium oxalate, ammonium acetate or ammonium 4-hydroxybenzoate salt of the compound of  claim 2 . 
     
     
       4. A method of promoting growth, efficiency of feed utilization and/or production of lean body mass in a livestock animal, comprising administering to the animal an effective amount of a compound represented by the following structural formula: 
                 
 
       or a physiologically acceptable salt thereof, wherein R1 is represented by a structural formula selected from the group consisting of: 
                 
                 
 
     
     
       5. The method of  claim 4  wherein the animal is a ruminant. 
     
     
       6. The method of  claim 5  wherein the ruminant is a cow, bull, heifer or steer. 
     
     
       7. The method of  claim 4  wherein the animal is an avian. 
     
     
       8. The method of  claim 7  wherein the avian is a chicken, turkey or duck. 
     
     
       9. A method of promoting growth, efficiency of feed utilization and/or production of lean body mass in a livestock animal, comprising administering to the animal an effective amount of a compound represented by the following structural formula: 
                 
 
       or a physiologically acceptable salt thereof. 
     
     
       10. The method of  claim 9  wherein the animal is a ruminant. 
     
     
       11. The method of  claim 10  wherein the ruminant is a cow, bull, heifer or steer. 
     
     
       12. The method of  claim 11  comprising administering the ammonium chloride, ammonium oxalate, ammonium acetate or ammonium 4-hydroxybenzoate salt of the compound. 
     
     
       13. The method of  claim 9  wherein the animal is an avian. 
     
     
       14. The method of  claim 13  wherein the avian is a chicken, turkey or duck. 
     
     
       15. The method of  claim 14  comprising administering the ammonium chloride, ammonium oxalate, ammonium acctate or ammonium 4-hydroxybenzoate salt of the compound. 
     
     
       16. A method of increasing the quantity of meat or improving the quality of meat obtained from a livestock animal, comprising administering to the animal an effective amount of one or more compounds represented by the following structural formula: 
                 
 
       or a physiologically acceptable salt thereof, wherein R1 is represented by a structural formula selected from the group consisting of: 
                 
 
     
     
       17. A method of increasing the quantity of meat or improving the quality of meat obtained from a livestock animal, comprising administering to the animal an effective amount of one or more compounds represented by the following structural formula: 
                 
 
       or a physiologically acceptable salt thereof. 
     
     
       18. The method of  claim 17  comprising administering the ammonium chloride, ammonium oxalate, ammonium acetate or ammonium 4-hydroxybenzoate salt of the compound. 
     
     
       19. An animal feed premix comprising a compound of Structural Formula I, as defined in  claim 1 , or a physiologically acceptable salt or solvate thereof, in association with a suitable carrier therefor. 
     
     
       20. An animal feed premix as claimed in  claim 19 , wherein the compound is 
                 
 
       or a physiologically acceptable salt or solvate thereof. 
     
     
       21. An animal feed composition comprising a compound of Structural Formula I, as defined in  claim 1 , or a physiologically acceptable salt or solvate thereof, in association with a suitable carrier therefor. 
     
     
       22. An animal feed composition as claimed in  claim 21 , wherein the compound is 
                 
 
       or a physiologically acceptable salt or solvate thereof.