Natural extracted and synthetic antioxidant compositions

Abstract

An antioxidant composition is isolated and purified from natural sources including yeast (S. carlsbergenesis, S. cerevisiae, or commercial yeast extract), and saltbush (Atriplex halimus), or synthesized chemically, by processes that improve the potency of the product. Compositions containing natural and synthetic compounds, with or without chromium, possessing antioxidant activity are formulated for use in animals and humans. Methods for use of the natural and synthetic antioxidants, alone or in combination with other antioxidant agents, for regulating oxidative conditions are presented.

What is claimed is:  
     
       1. A natural antioxidant composition with or without chromium, isolated from a yeast strain comprising of  S. carlsbergensis.    
     
     
       2. The antioxidant composition according to claim  1  further comprising an antioxidant selected from the group consisting of vitamin C, vitamin E, reduced glutathione, manganese, beta-carotene, ergothioneine, zinc, selenium, cysteine, N-acetyl cysteine, methionine or 2-mercaptoethanol. 
     
     
       3. A purified chromium containing natural antioxidant isolated from a saltbush. 
     
     
       4. The antioxidant composition of claim  3  further comprising an antioxidant selected from the group consisting of vitamin C, vitamin E, reduced glutathione, manganese, beta-carotene, ergothioneine, zinc, selenium, cysteine, N-acetyl cysteine, methionine or 2-mercaptoethanol. 
     
     
       5. The antioxidant composition according to claim  4 , said composition being suitable for administering to a human subject suffering from a condition including hyperglycemia, hypertriglyceridemia, hypercholesterolemia, peripheral vascular disease, neuropathy, inflammatory diseases, warts, cell proliferative diseases, eczema, anthropathy, psoriasis or glucose intolerance. 
     
     
       6. A process for producing an antioxidant complex said process comprising the steps of: 
       (i) reacting a metal salt with a material possessing antioxidant activity to form a reaction mixture,  
       (ii) stirring the reaction mixture at 40° C. until a desired color is obtained, and  
       (iii) eluting all material having an appropriate molecular weight.  
     
     
       7. The process according to claim  6 , wherein the material possessing antioxidant activity comprises, cysteine, glutathione, glucono-lactone, N-acetyl cysteine or methionine. 
     
     
       8. The process according to claim  6 , wherein the metal salt comprises chromium chloride, magnesium chloride, manganese chloride, zinc chloride, molybdenum chloride, or boron chloride. 
     
     
       9. A method for regulating free radical production, said method comprising administering an effective amount of a antioxidant composition with or without chromium, wherein the antioxidant is isolated from natural sources including yeast or saltbush.