Phosgenated oxime resins and their preparation

Abstract

This invention relates to methods for preparing novel, solid-phase transfer reagents, specifically phosgenated oxime resins and non-symmetrical ureas, that are useful as supports in combinatorial synthesis for the creation of libraries of compounds for lead identification.

I claim: 
     
       1. A method of phosgenation comprising: contacting a compound to be phosgenated with an excess of a phosgene source in the form of a solid phase reagent of the formula ##STR33## wherein Z is the recurring part of a carbonaceous polymeric backbone or side chain thereof, Y is a pendant group of the recurring part of the carbonaceous backbone, and EWG is an electron withdrawing group.   
     
     
       2. A method of using a solid phase reagent as a phosgene transfer reagent comprising contacting the solid phase reagent of the formula ##STR34## wherein Z is the recurring part of a carbonaceous polymeric backbone or side chain thereof, Y is a pendant group of the recurring part of the carbonaceous backbone, and EWG is an electron withdrawing group with a compound to be phosgenated. 
     
     
       3. A process for preparing a solid phase reagent useful in chemical synthesis comprising: reacting an excess of phosgene with a ketoxime of the formula ##STR35## wherein Z is the recurring part of a carbonaceous polymeric backbone or side chain thereof and EWG is at least one electron-withdrawing group unreactive to phosgene, to produce the corresponding oxime-derived chloroformate.