Topical fluoroquinolone antibiotics in an alcohol and acetone vehicle

Abstract

A method of treating bacterial infections of the skin comprising topically administering a pharmaceutical composition comprising fluoroquinolones selected from the group consisting of ciprofloxacin, ofloxacin, enoxacin, cinoxacin, pefloxacin, lomefloxacin, norfloxacin, tosufloxacin, fleroxacin, temafloxacin, trovafloxacin and difloxacin, mixed in an alcohol acetone vehicle is disclosed. The topical carrier will be in the form of a cream, ointment, lotion, gel, suspension, emulsion, cleansing bar, pledget, salve, tincture, spray, transdermal device, or other appropriate non-toxic pharmaceutical vehicle.

I claim: 
     
       1. A method of topically treating bacterial infections of the skin caused by susceptible organisms which comprises administering to an individual a composition of a fluoroquinolone antibiotic present in a vehicle containing acetone and alcohol, applied directly to the affected areas of the human skin. 
     
     
       2. The method described in claim 1 wherein the fluoroquinolone antibiotic is selected from a group consisting of ciprofloxacin, ofloxacin, enoxacin, cinoxacin, pefloxacin, lomefloxacin, norfloxacin, tosufloxacin, fleroxacin, temafloxacin, trovafloxacin, and difloxacin, in a topical agent, in the form of an ointment, cream, lotion, gel, suspension, emulsion, cleansing bar, pledget, salve, tincture, spray, transdermal device, or other appropriate non-toxic pharmaceutical carrier. 
     
     
       3. The method described in claim 1 wherein the fluoroquinolone antibiotic is present in a range from about 5% to about 10% by weight of the composition. 
     
     
       4. The method described in claim 1 wherein the alcohol and acetone is present in a weight percent from 0.1% to 95.0%. 
     
     
       5. A method described in claim 1 wherein the topical carrier is present in a weight percent from 75.0% to 94.9%.