US5847193AExpiredUtility

Labelled compound

Priority: Mar 24, 1995Filed: Mar 22, 1996Granted: Dec 8, 1998

Est. expiryMar 24, 2015(expired)· nominal 20-yr term from priority

Inventors:Yasuyoshi Watanabe Hironori Omura Yuji Furuya Bengt Langstrom Gunnar Antoni

A61K 2123/00A61K 51/0406

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References

Claims

Abstract

The present invention provides a labelled beta -cyano-L-alanine and a gamma -cyano- alpha -aminobutyric acid, of which cyano group carbon is labelled with radionuclide 11C or 14C, or stable isotope 13C. The present invention also provides a labelled amino acids such as asparagine, asparatic acid, DABA, GABA, glutamine and glutamic acid synthesized by using the labelled beta -cyano-L-alanine and the gamma -cyano- alpha -aminobutyric acid as an intermediate. The labelled amino acids are useful for in vivo imaging of tumors and brain functions.

Claims

exact text as granted — not AI-modified

What is claimed is: 
     
       1. A labelled compound, which is β-cyano-L-alanine, a salt thereof or a derivative thereof having protecting group, of which cyano group carbon is labelled with positron nuclide  11  C.

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