US5760244AExpiredUtility

Process for the preparation of 3-isoxazolecarboxylic acid

Assignee: SHIONOGI & COPriority: Feb 16, 1994Filed: Jul 28, 1997Granted: Jun 2, 1998

Est. expiryFeb 16, 2014(expired)· nominal 20-yr term from priority

Inventors:Susumu Takada Nobuo Chomei Masaaki Uenaka

Y02P20/55C07D 261/04C07D 263/34C07D 261/18

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Claims

Abstract

A process for the preparation of 3-isoxazolecarboxlic acid which is an intermediate for prepearing useful compounds is provided, said process being characterized in that a compound of formula (I) is reacted with hydroxylamine to obtain a compound of formula (II), and the compound thus obtained is treated with an alkali: ##STR1## wherein R 1 is a lower alkyl, R 2 is a carboxy protecting group, X is a halogen atom, and Y is a hydrogen atom, or X and Y together may form a single bond.

Claims

exact text as granted — not AI-modified

What is claimed is: 
     
       1. A process for the preparation of 3-isoxazolecarboxylic acid of the formula (III): ##STR15## characterized in that a compound of the formula (II): ##STR16## wherein R 1  is a lower alkyl and R 2  is a carboxy protecting group, is treated with an alkali.

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