Antibiotics 10381v, w, x,y, z1, z2, pre-b and t

Abstract

PCT No. PCT/US94/09647 Sec. 371 Date Mar. 7, 1996 Sec. 102(e) Date Mar. 7, 1996 PCT Filed Sep. 6, 1994 PCT Pub. No. WO95/07292 PCT Pub. Date Mar. 16, 1995Antibiotics 10381v, w, x, y, z1, z2, pre-b and t are antibiotics producible by culturing the microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. The structure of Antibiotic 10381y is given below as formula IV. These antibiotics inhibit the growth of selected species of bacteria and may also be useful as a growth promotant in animals. <IMAGE> IV

We claim: 
     
       1. An isolated and purified compound of the formula I, II, III, IV, V, VI, VII, or IX: or pharmaceutically acceptable salts thereof.   
     
     
       2. The compound of formula I, II, III, IV, V, VI, VII, or IX of claim 1, except as existing or occurring in nature. 
     
     
       3. The compound of formula I, II, III, IV, V, VI, VII, or IX of claim 2 in essentially pure form. 
     
     
       4. The compound of formula IV of claim 1 which is 52-de 1-   1-(aminocarbonyl)ethenyl!amino!carbonyl!ethenyl!-sulfomycin I. 
     
     
       5. A feed composition, which comprises animal feed and an amount effective to promote growth of a compound of the formula I, II, III, IV, V, VI, VII, or IX of claim 1, or any combination thereof. 
     
     
       6. An animal premix which comprises an amount effective to promote growth of a compound of the formula I, II, III, IV, V, VI, VII, or IX of claim 1, or any combination thereof, and a suitable inert carrier therefor. 
     
     
       7. A method for promoting growth in animals which comprises administering to the animals an effective amount of a compound of the formula I, II, III, IV, V, VI, VII, or IX of claim 1, or any combination thereof. 
     
     
       8. The method of claim 7 wherein the animals are selected from the group consisting of poultry, sheep, cattle, and swine. 
     
     
       9. The method of claim 8 wherein the animals are chickens. 
     
     
       10. The method of claim 9 wherein the compound is administered orally in an amount of about 0.5 to about 11 mg/kg of feed. 
     
     
       11. The method of claim 8 wherein the animals are swine. 
     
     
       12. The method of claim 11 wherein the compound is administered orally in an amount of about 1 to about 55 mg/kg of feed.