US5603934AExpiredUtility

Antigen recognized by patients with antibody associated paraneoplastic sensory neuronopathy

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Assignee: SLOAN KETTERING INST CANCERPriority: Mar 4, 1991Filed: Mar 18, 1994Granted: Feb 18, 1997
Est. expiryMar 4, 2011(expired)· nominal 20-yr term from priority
Inventors:Jerome B. PosnerHenry M. Furneaux
C07K 14/705C07K 16/3023C07K 16/3053A61K 38/00
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PatentIndex Score
5
Cited by
16
References
3
Claims

Abstract

An isolated nucleic acid sequence encoding Hu paraneoplastic antigenic polypeptide is provided by this invention. This invention also provides a purified Hu antigenic polypeptide and compositions containing the purified Hu antigenic polypeptide. Further provided by this invention is a monoclonal antibody directed to an epitope on the Hu paraneoplastic antigenic polypeptide. Compositions containing this monoclonal antibody also are provided by this invention. This invention also provides methods of diagnosis and treatment using the compositions described hereinabove.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A recombinant human Hu antigenic polypeptide which comprises an antigenic epitope that is recognized by autoantibodies from patients with paraneoplastic sensory neuronopathy, said polypeptide having been expressed in Escherichia coli by the plasmid pHB1.5 (ATCC Accession Number 40986). 
     
     
       2. The antigenic polypeptide of claim 1 labelled with a detectable marker. 
     
     
       3. The antigenic polypeptide of claim 2, wherein the detectable marker is a radioisotope, dye, enzyme or biotin.

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