Nasal pharmaceutical composition

Abstract

A pharmaceutical composition adapted for nasal administration and comprising hPTH or a N-terminal fragment thereof. Preferred carriers are optionally coated celluloses.

We claim: 
     
       1. A compound of formula I ##STR3## wherein X 1  is Ser or Ala, X 2  is Leu or Ala, and   X 3  is OH or NH 2   in free form or in the form of a salt or complex.     
     
     
       2. A pharmaceutical composition comprising a compound of formula I as defined in claim 1 in free form or in pharmaceutically acceptable salt form or complex form in association with a pharmaceutically acceptable carrier or diluent. 
     
     
       3. A method for preventing or treating osteoporosis, in a subject in need of such treatment, which method comprises administering to said subject an effective amount of a compound of formula I as defined in claim 1 or a pharmaceutically acceptable salt or complex thereof. 
     
     
       4. The compound of claim 1 wherein said salt form and complex form are pharmaceutically acceptable. 
     
     
       5. The composition of claim 2 wherein said composition is the form of a nasal spray, drop, gel, powder or insert. 
     
     
       6. The method of claim 3 wherein said compound or pharmaceutically acceptable salt or complex thereof is administered nasally. 
     
     
       7. A method for stimulating bone resorption and for stimulating bone cell proliferation, in a subject in need of such stimulation, comprising administering to said subject an effective amount of a compound of formula I as defined in claim 1 or a pharmaceutically acceptable salt or complex thereof. 
     
     
       8. The method of claim 7 wherein said compound or pharmaceutically acceptable salt or complex thereof is administered nasally.