Process for the preparation of prefilled syringes without residual gas bubbles

Abstract

A process for the production of prefilled syringes free from dangerous residual air or gas bubbles, in short production times.

I claim: 
     
       1. A process for the production of prefilled syringes free from residual gas or air bubbles in a dangerous amount for the patient's health, characterized by the following steps: a syringe nozzle is temporarily sealed with a suitable removable cap,   from an opposite opened end of said syringe at least 80% of a desired volume/dosage solution to be injected is loaded, then a plunger-piston is inserted under vacuum,   the syringe is turned, the cap is removed and, through the nozzle, the syringe is completely filled with a remaining quantity of said solution to be injected,   the syringe is re-sealed by re-inserting the cap on the tip of said syringe nozzle, optionally under vacuum.   
     
     
       2. A process according to claim 1, in which the amount of injectable solution loaded through the syringe open end is at least 95% of the total dosage, of said solution. 
     
     
       3. A prefilled syringe according to the process of claim 1, in which said syringe is filled with a pharmaceutical injectable solution. 
     
     
       4. A prefilled syringe according to the process of claim 1, in which said syringe is filled with a contrastographic injectable solution for in vivo diagnostic procedures. 
     
     
       5. A prefilled syringe according to the process of claim 1, in which said syringe is made of plastic.