US5541230AExpiredUtility

Therapeutic polyamines

94
Assignee: US HEALTHPriority: Nov 5, 1993Filed: Nov 5, 1993Granted: Jul 30, 1996
Est. expiryNov 5, 2013(expired)· nominal 20-yr term from priority
Inventors:Hirak S. BasuBurt G. FeuersteinLaurence J. MartonKeijiro Samejima
C07C 211/14
94
PatentIndex Score
77
Cited by
29
References
2
Claims

Abstract

Therapeutic polyamines useful as a cancer chemotherapeutic agents, including molecules having a formula R 1 --NH--(CH 2 ) x --NH --(CH 2 ) x --NH--(CH 2 ) y --NH--(CH 2 ) z --NH--R, wherein R 1 and R 2 are hydrocarbon chains having 1 to 5 carbons and w, x, y and z are integers of 1 to 10, are disclosed. One such molecule is N 1 , N 19 -bis(ethylamino)-5,10,15-triazanonadecane, which is longer than spermine. This preferred compound may be used alone or in combination with other therapeutic agents, such as 1,3-bis(2-chloroethyl)-1-nitrosourea or cis-Pt.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. An antineoplastic composition comprising N 1 , N 19  -bis(ethylamino)-5,10,15-triazanonadecane in a pharmaceutically acceptable carrier. 
     
     
       2. An antineoplastic composition according to claim 1, wherein said carrier is aqueous.

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