US5418218AExpiredUtility

Histidyl-proline diketopiperazine (cyclo his-pro) a cns-active pharmacologic agent

Assignee: UNIV MARYLANDPriority: Jul 10, 1992Filed: Jul 10, 1992Granted: May 23, 1995

Est. expiryJul 10, 2012(expired)· nominal 20-yr term from priority

Inventors:John F. Wilber

C07K 5/12A61K 38/00A61K 31/498

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Claims

Abstract

A stable peptide with a direct effect on the central nervous system that can be administered in a general manner, such as orally, is described.

Claims

exact text as granted — not AI-modified

I claim: 
     
       1. A method comprising administering to a primate orally an effective amount of histidyl-proline diketopiperazine (cyclo (His-Pro)) for enhancing satiety. 
     
     
       2. The method of claim 1, wherein said cyclo (His-Pro) is added to a food. 
     
     
       3. A method of controlling food intake in a primate comprising administering to said primate orally an amount of cyclo (His-Pro) effective to enhance satiety. 
     
     
       4. The method of claim 3, wherein said cyclo (His-Pro) is added to a food. 
     
     
       5. A method comprising orally administering to a primate an amount of cyclo (His-Pro) effective for enhancing satiety. 
     
     
       6. The method of claim 5 wherein said cyclo (His-Pro) is added to a food.

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