Phenoxypropanolamine compounds

Abstract

Compounds of the formula (I): ##STR1## wherein R 1 is hydrogen or fluoro and R 2 is hydrogen or C1-6 alkyl and salts thereof are described as agents for the treatment of obesity and related conditions. Processes for their preparation and intermediates are described.

We claim: 
     
       1. A compound of the formula (I): ##STR16## wherein R 1  is hydrogen or fluoro and R 2  is hydrogen or C 1-6  alkyl, or a pharmaceutically acceptable salt thereof. 
     
     
       2. A compound according to claim 1 wherein R 1  is hydrogen and the --OCH 2  COR 2  substituent and the phenoxypropylaminoethoxy substituent are in para-relationship. 
     
     
       3. A compound according to claim 1 wherein R 2  is C 1-6  alkyl. 
     
     
       4. A compound according to claim 3 wherein R 2  is methyl or ethyl. 
     
     
       5. A compound according to claim 1 when in (S) absolute configuration at the --CH(OH)-- group. 
     
     
       6. A compound according to claim 1 which is: 1-[4-(2-(2-hydroxy-3-phenoxypropylamino)ethoxy)phenoxy]propan-2-one,   1-[4-(2-(2-hydroxy-3-phenoxypropylamino)ethoxy)phenoxy]butan-2-one,   (S)-1-[4-(2-(2-hydroxy-3-phenoxypropylamino)ethoxy)phenoxy]propan-2-one or   (S)-1-[4-(2-(2-hydroxy-3-phenoxypropylamino)ethoxy)phenoxy]butan-2-one.   
     
     
       7. A pharmaceutical composition which comprises a compound according to claim 1 or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.