US5153219AExpiredUtility

Thiocarbamate sulfoxide composition for deterring ethanol ingestion

33
Individually held — no corporate assignee on recordPriority: Apr 22, 1991Filed: Apr 22, 1991Granted: Oct 6, 1992
Est. expiryApr 22, 2011(expired)· nominal 20-yr term from priority
Inventors:Morris FaimanBruce W. HartAjay Madan
A61P 25/30A61P 3/00A61P 25/32A61K 31/145A61K 31/325
33
PatentIndex Score
7
Cited by
45
References
15
Claims

Abstract

A method is provided for deterring ethanol ingestion by a human, comprising administering to said human an amount of a compound of the formula (R 1 ) R 2 )NC(X)S(O)R 3 effective to cause the disulfiram-ethanol reaction in said human, wherein R 1 , R 2 and R 3 are each (C 1 -C 4 ) alkyl groups, e.g., methyl, ethyl, propyl, isopropyl, butyl, i-butyl and t-butyl.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A method for deterring ethanol ingestion by a human comprising administering to said human a pharmaceutical unit dosage form comprising an amount of a compound of the formula: ##STR2## wherein R 1 , R 2  and R 3  are individually (C 1  -C 4 ) alkyl, X is O or S, and the pharmaceutically acceptable salts thereof, which is effective to increase the blood acetaldehyde concentration of said human in the presence of ethanol. 
     
     
       2. The method of claim 1 wherein X is S. 
     
     
       3. The method of claim 1 wherein X is O. 
     
     
       4. The method of claim 1 wherein R 1  and R 2  are individually methyl or ethyl. 
     
     
       5. The method of claim 4 wherein R 3  is methyl. 
     
     
       6. The method of claim 4 wherein the compound is S-methyl-N,N-diethylthiolcarbamate sulfoxide. 
     
     
       7. The method of claim 2 wherein the compound is S-methyl-N,N-diethyldithiocarbamate sulfoxide. 
     
     
       8. A pharmaceutical unit dosage form comprising an amount of a compound of the formula: ##STR3## wherein R 1  and R 2  are individually methyl or ethyl, X is S or O, and the pharmaceutically-acceptable salts thereof; in combination with a pharmaceutically-acceptable carrier, wherein said amount is effective to increase the blood acetaldehyde concentration of a human in the presence of ethanol following administration thereto. 
     
     
       9. The pharmaceutical unit dosage form of claim 8, wherein the compound is S-methyl-N,N-diethylthiolcarbamate sulfoxide. 
     
     
       10. The pharmaceutical unit dosage form of claim 8, wherein the compound is S-methyl-N,N-diethyldithiocarbamate sulfoxide. 
     
     
       11. The pharmaceutical unit dosage form of claim 8 wherein R 1  =R 2  =ethyl. 
     
     
       12. The pharmaceutical unit dosage form of claim 8 wherein X is O. 
     
     
       13. The pharmaceutical unit dosage form of claim 8 wherein X is S. 
     
     
       14. The pharmaceutical unit dosage form of claim 8 wherein the pharmaceutically-acceptable carrier is a liquid diluent. 
     
     
       15. The pharmaceutical unit dosage form of claim 8 wherein the pharmaceutically acceptable carrier is an ingestible capsule.

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