Process for the preparation of 2-amino-4-methyl-6-methoxy-1,3,5-triazine

Abstract

A process for preparing 2-amino-4-methyl-6-methoxy-1,3,5-triazine by reacting dialkyl-N-cyanoimidocarbonate with acetamidine hydrochloride or an O-alkylacetamidate hydrochloride under basic conditions.

What is claimed is: 
     
       1. A method for making 2-amino-4-methyl-6-methoxy-1,3,5-triazine comprising reacting dialkyl-N-cyanoimidocarbonate of the formula ##STR2## wherein R 1  is C 1  -C 3  alkyl with acetamidine hydrochloride or an O-alkylacetamidate hydrochloride under basic conditions. 
     
     
       2. A method according to claim 1 wherein dialkyl-N-cyanoimidocarbonate is reacted with acetamidine hydrochloride. 
     
     
       3. A method according to claim 1 wherein dialkyl-N-cyanoimidocarbonate is reacted with an O-alkylacetamidate hydrochloride. 
     
     
       4. A method according to claim 1 comprising reacting the ingredients in the presence of an aqueous or organic solvent and an organic or inorganic base. 
     
     
       5. A method according to claim 1 wherein the solvent is selected from the group water, methanol, acetonitrile and toluene and the base is selected from the group triethylamine, sodium hydroxide, sodium methoxide and potassium hydroxide. 
     
     
       6. A method according to claim 5 wherein the solvent is methanol and the base is selected from the group sodium hydroxide, potassium hydroxide and sodium methoxide. 
     
     
       7. A method according to claim 2 comprising reacting the ingredients in the presence of an aqueous or organic solvent and an organic or inorganic base. 
     
     
       8. A method according to claim 7 wherein the solvent is selected from the group water, methanol, acetonitrile and toluene and the base is selected from the group triethylamine, sodium hydroxide, sodium methoxide and potassium hydroxide. 
     
     
       9. A method according to claim 8 wherein the solvent is methanol and the base is selected from the group sodium hydroxide, potassium hydroxide and sodium methoxide. 
     
     
       10. A method according to claim 3 comprising reacting the ingredients in the presence of an aqueous or organic solvent and an organic or inorganic base. 
     
     
       11. A method according to claim 10 wherein the solvent is selected from the group water, methanol, acetonitrile and toluene and the base is selected from the group triethylamine, sodium hydroxide, sodium methoxide and potassium hydroxide. 
     
     
       12. A method according to claim 11 wherein the solvent is methanol and the base is selected from the group sodium hydroxide, potassium hydroxide and sodium methoxide. 
     
     
       13. A method according to claim 2 comprising reacting dialkyl-N-cyanoimidocarbonate with acetamidine, the reaction product of acetamidine hydrochloride and base. 
     
     
       14. A method according to claim 3 comprising reacting dialkyl-N-cyanoimidocarbonate with an O-alkylacetamidate the reaction product of an O-alkylacetamidate hydrochloride and base.