US5057522AExpiredUtility

Anti-hypersensitive N2-tetrazole-β-glucuronide analog

82
Assignee: MERCK & CO INCPriority: Jul 19, 1990Filed: Jul 19, 1990Granted: Oct 15, 1991
Est. expiryJul 19, 2010(expired)· nominal 20-yr term from priority
Inventors:Shieh-Shung T. ChenGeorge Doss
C12P 19/28C07H 19/056C07D 471/04
82
PatentIndex Score
21
Cited by
1
References
3
Claims

Abstract

Fermentation of the microorganism Streptomyces sp. MA6751 in the presence of ##STR1## yields an anti-hypertensive compound of the structure ##STR2##

Claims

exact text as granted — not AI-modified
What is claimed: 
     
       1. A compound of structural formula (I): ##STR7## 
     
     
       2. An antihypertensive pharmaceutical composition comprising a non-toxic therapeutically effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier. 
     
     
       3. A method of treating hypertension of congestive heart failure comprising the administration of a non-toxic therapeutically effective amount of the compound of claim 1 to a subject in need of such treatment.

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