US4814487AExpiredUtility

Amido substituted naphthalenes and intermediates thereof

Assignee: ORTHO PHARMA CORPPriority: Sep 26, 1986Filed: May 7, 1987Granted: Mar 21, 1989

Est. expirySep 26, 2006(expired)· nominal 20-yr term from priority

Inventors:William V. Murray Michael P. Wachter

C07C 59/90

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Claims

Abstract

The synthesis of amido substituted naphthalenes and their intermediates is described. The intermediates and amido substituted naphthalenes are useful as anti-inflammatory agents.

Claims

exact text as granted — not AI-modified

What is claimed is: 
     
       1. A compound selected from the group consisting of Ethyl 6-(6-allyloxy-2-naphthyl)-6-oxohexanoate, methyl 8-(6-methoxy-2-naphthyl)-8-oxooctanoate, ethyl 6-(6-benzyloxy-2-naphthyl)-6-oxohexanoate, methyl 6-(6-benzyloxy-2-naphthyl)-6-oxohexanoate, 6-(6-benzyloxy-2-naphthyl)-6-oxohexanoic acid, and methyl 6-(6-allyloxy-2-naphthyl)-6-oxohexanoate. 
     
     
       2. A Compound selected from the group consisting of 6-(6-allyloxy-2-naphthyl)-6-oxohexanoic acid, ethyl 6-(6-propargyloxy-2-naphthyl)-6-oxohexanoate, methyl 6-(6-propargyloxy-2-naphthyl)-6-oxohexanoate, 6-(6-propargyloxy-2-naphthyl)-6-oxohexanoic acid, ethyl 6-[6-(3-methylbutyloxy)-2-naphthyl]-6-oxohexanoate, and methy 6-[6-(3-methylbutyloxy)-2-naphthyl]-6-oxohexanoate. 
     
     
       3. A compound selected from the group consisting of 6-[6-(3-methylbutyloxy)-2-naphthyl]-6-oxohexanoic acid, ethyl 6-[6-(1-methylbutyloxy)-2-naphthyl]-6-oxohexanote, methyl 6-[6-(1-methylbutyloxy-2-naphthyl]-6-oxohexanoate, 6-[6-(1-methylbutyloxy)-2-naphthyl]-6-oxohexanoic acid, ethyl 8-(6-methoxy-2-naphthyl)-8-oxooctanoate, and 8-(6-methoxy-2-naphthyl)-8-oxooctanoic acid.

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