Medicaments with a high degree of solubility and method for their production

Abstract

The present invention relates to medicaments with a high degree of dissolution rate and solubility. These medicaments are characterized in that they are in amorphous form produced by spraying in the presence of a stabilizer and of an agent inhibiting the formation of crystals.

We claim: 
     
       1. A process for the preparation of a stable pharmaceutical dipyridamole composition with a high dissolution rate in the gastrointestinal tract, in which dipyridamole is in amorphous form, comprising the steps of: (a) dissolving non-amorphous crystalline dipyridamole in a pharmaceutically acceptable solvent constituted by water, a low molecular weight C 1  to C 4  alcohol, or mixtures thereof, with a stabilizing and crystal-formation-inhibiting amount of 5% w/w to 35% w/w of polyvinylpyrrolidone with respect to the weight of the dipyridamole;   (b) heating said solution to about 110° to about 150° C.; and   (c) atomizing said heated solution at an input temperature of about 110° to about 150° C. in a sprayer such that the output temperature is between about 80° and about 120° C., to obtain stable amorphous dipyridamole-polyvinylpyrrolidone.