Meta-sulfonamido-benzamides

Abstract

Meta-sulfonamido-benzamide derivatives of the formula: ##STR1## [wherein R is a hydrogen atom or a lower alkyl, cyano, or lower alkanesulfonyl group; R 1 is a lower alkyl, phenyl, amino, lower alkylamino, di(lower)alkylamino, or C 4 -C 5 alkyleneamino group; R 2 is a hydrogen or halogen atom or a lower alkyl, di(lower)alkylamino, or lower alkoxy group; R 3 is a hydrogen atom or a methyl or methoxy group; R 4 is a hydrogen or halogen atom; R 5 is a lower alkyl, lower alkenyl, C 3 -C 6 cycloalkyl, benzyl, or halogenobenzyl group; and n is 1 or zero] or their acid addition salts, showing pharmacological activity such as anti-emetic or psychotropic activity, are provided via several routes.

What we claim is: 
     
       1. A compound selected from the group consisting of a compound of the formula ##STR22## wherein R is methyl or cyano, R 1  is methyl or ethyl, and R 2  is hydrogen, methyl or chlorine, and a pharmaceutically acceptable acid addition salt thereof.   
     
     
       2. A compound according to claim 1, namely N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-5-(N-cyanomethanesulfonamido)benzamide. 
     
     
       3. A compound according to claim 1, namely N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-5-(N-methylethanesulfonamido)benzamide. 
     
     
       4. A compound according to claim 1, namely N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-4-chloro-5-(N-methylmethanesulfonamido)benzamide.