US4281190AExpiredUtility

Process for preparing N-[2-(p-hydroxyphenyl)-ethyl]-p-chlorobenzamide

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Assignee: MORTON NORWICH PRODUCTS INCPriority: Aug 14, 1980Filed: Aug 14, 1980Granted: Jul 28, 1981
Est. expiryAug 14, 2000(expired)· nominal 20-yr term from priority
Inventors:Nicholas Harris
C07D 263/42
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PatentIndex Score
0
Cited by
4
References
1
Claims

Abstract

A process for preparing N-[2-(p-hydroxyphenyl)ethyl]-p-chlorobenzamide, a penultimate precursor for bezafibrate, is described.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. The method of preparing N-[2-(p-hydroxyphenyl)ethyl]-p-chlorobenzamide which consists in: (a) reacting N-(p-chlorobenzoyl)glycine and p-hydroxybenzaldehyde in the presence of sodium acetate and acetic anhydride to form 4-(p-acetoxybenzylidene)-2-(p-chlorophenyl)-5-oxazolone; (b) treating said oxazolone with sodium hydroxide to form 2-(p-chlorobenzamido)-3-(p-hydroxyphenyl)acrylic acid; (c) decarboxylating said acrylic acid to form 1-(p-chlorobenzamido)-2-(p-(hydroxyphenyl)ethylene; and (d) hydrogenating said ethylene.

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