US4239780AExpiredUtility

Phospholipase A2 inhibition

82
Assignee: UPJOHN COPriority: Oct 11, 1979Filed: Oct 11, 1979Granted: Dec 16, 1980
Est. expiryOct 11, 1999(expired)· nominal 20-yr term from priority
Inventors:Donald P. Wallach, Deceased
A61K 31/135
82
PatentIndex Score
39
Cited by
1
References
1
Claims

Abstract

Phospholipase A 2 inhibition the present invention relates to a method for treating or preventing a phospholipase A 2 mediated condition (PMC) in a mammal suffering from or susceptible to such a condition. The method involves administering to such a mammal an amount effective to treat the condition of a compound selected from a certain group of butyrophenones.

Claims

exact text as granted — not AI-modified
I claim: 
     
       1. A method for treating a phospholipase A 2  mediated condition (PMC) in a mammal suffering from the development of said PMC which comprises administering to said mammal an amount of a compound of formula I: wherein R 1  is R 1  --N(R 3 )--CH 2  --CH 2  --CH 2  --R 2  ##STR16## R 2  is ##STR17## R 3  is H or CH 3 , with the proviso that R 3  is -CH 3  only when R 1  is ##STR18##  or a pharmacologically acceptable acid addition salt or salt hydrate thereof, effective to treat said PMC.

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