Process for treating inflammation

Abstract

A process for treating inflammation locally or topically by administering a compound of the formula: ##STR1## wherein M and M' are hydrogen, hydroxy, halogen, lower alkyl of from 1 to 3 carbon atoms, lower alkoxy of from 1 to 3 carbon atoms; NH 2 , RNH, R' 2 N where R is lower alkyl of from 1 to 3 carbon atoms or lower acyl of from 1 to 3 carbon atoms and R' is lower alkyl of from 1 to 3 carbon atoms; X, Y and Z are hydrogen, hydroxy, halogen, lower alkoxy of from 1 to 3 carbon atoms or lower acyloxy of from 1 to 6 carbon atoms, in association with appropriate pharmaceutical carriers.

I claim: 
     
       1. A process for treating inflammation comprising the administration topically or by local injection to a human or animal of an effective anti-inflammatory amount of a compound of the formula: ##STR3## wherein M and M' are hydrogen, hydroxy, halogen, lower alkyl of from 1 to 3 carbon atoms, lower alkoxy of from 1 to 3 carbon atoms; X, Y and Z are hydrogen, hydroxy, halogen, lower alkoxy of from 1 to 3 carbon atoms or lower acyloxy of from 1 to 6 carbon atoms, in association with appropriate pharmaceutical carriers. 
     
     
       2. The process of claim 1 wherein M' is hydrogen. 
     
     
       3. The process of claim 1 where the compound is 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone. 
     
     
       4. The process of claim 1 where the compound is 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone. 
     
     
       5. A pharmaceutical composition for treatment of inflammation in humans or animals comprising an effective anti-inflammatory amount of a compound of the formula: ##STR4## wherein M and M' are hydrogen, hydroxy, halogen, lower alkyl of from 1 to 3 carbon atoms, lower alkoxy of from 1 to 3 carbon atoms; X, Y and Z are hydrogen, hydroxy, halogen, lower alkoxy of from 1 to 3 carbon atoms or lower acyloxy of from 1 to 6 carbon atoms, in association with appropriate topical or injectable pharmaceutical carriers. 
     
     
       6. The composition of claim 5 wherein M' is hydrogen. 
     
     
       7. The composition of claim 5 wherein the compound is 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone. 
     
     
       8. The composition of claim 5 wherein the compound is 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone.