US4107161AExpiredUtility

Bis(triamcinolone acetonide)-4,4'-methylenebis-(3-methoxy-2-naphthoate)

53
Assignee: URIACH & CIA SA JPriority: May 13, 1972Filed: Mar 18, 1974Granted: Aug 15, 1978
Est. expiryMay 13, 1992(expired)· nominal 20-yr term from priority
Inventors:Agustin Agusti
C07J 71/0031
53
PatentIndex Score
10
Cited by
1
References
5
Claims

Abstract

Bis(triamcinolone acetonide) 4,4'-methylene-bis(3-methoxy-2-naphthoate), method of preparing the same by preparing a reactive derivative of 4,4'-methylene-bis(3-methoxy-2-naphthoic acid) and reacting such derivative with triamcinoline acetonide. The triamcinolone acetonide derivative is particularly suitable for use in the treatment of dermatosis, eczema, neurodermatitis, impetigo, psoriasis, pruritis, erythema and the like.

Claims

exact text as granted — not AI-modified
I claim: 
     
       1. Bis(triamcinolone acetonide)4,4'-methylene-bis(3-methoxy-2-naphthoate). 
     
     
       2. A process for the preparation of the compound of claim 1 comprising preparing a halide of 4,4'-methylenebis(3-methoxy-2-naphthoic acid) and reacting the said halide with triamcinolone acetonide in the presence of an agent for fixing the hydrogen halide that is formed during the reaction. 
     
     
       3. A process according to claim 2 in which the halide is the chloride. 
     
     
       4. A process according to claim 2 in which the agent for fixing the hydrogen halide is an organic base. 
     
     
       5. A process according to claim 4 in which the organic base is pyridine.

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