6-Spirocycloalkylamino 5-nitropyrimidines

Abstract

Novel pteridines of formula (I), ##SPC1## wherein R is a lower alkyl group, optionally substituted with a hydroxy group and R 1 and R 2 are the same or different and each is a lower alkyl group having together at least 3 carbon atoms or R 1 and R 2 , together with the carbon atom in the pteridine ring structure, form a spirocycloalkyl ring system having 4 to 6 carbon atoms outside the pteridine ring structure, and their method of preparation. The above compounds have bacteriostatic activity.

What we claim is: 
     
       1. A compound of the formula, or a tautomeric form thereof ##SPC5## wherein Z is oxygen or a protecting group therefore, R is lower alkyl or hydroxylower alkyl, and R 1  and R 2 , having in total 4 to 6 carbon atoms, form a spirocycloalkyl group together with the carbon atom substituted by said R 1  and R 2 .   
     
     
       2. The compound according to claim 1, which is 2-Amino-4-hydroxy-6-(3-hydroxy-2-hydroxyimino-1-spirocyclohexylpropylamino)-5-nitropyrimidine.