Substituted 2-phenyl-4,6,7,8-tetrahydrofuro and 1,4,5,6,7,8-hexahydropyrrolo[3,2,-c]azepines

Abstract

Substituted 2-phenyl-4,6,7,8-tetrahydrofuro- and 1,4,5,6,7,8-hexahydropyrrolo[3,2-c]azepines and physiologically tolerable acid addition salts thereof possessing analgesic and tranquilizing properties, and a process for their preparation are described.

We claim: 
     
       1. A compound of the formula ##SPC2## wherein R is alkanoyl of from 2 to 6 carbon atoms, haloalkanoyl of from 2 to 6 carbon atoms, alkoxycarbonyl of from 2 to 6 carbon atoms, cycloalkylcarbonyl of from 4 to 7 carbon atoms, benzoyl, alkoxybenzoyl of from 8 to 10 carbon atoms, halobenzoyl or halobenzoylalkyl of from 8 to 11 carbon atoms, and a physiologically tolerable acid addition salt thereof.   
     
     
       2. A compound as defined in claim 1 in which R is acetyl, propionyl, butyryl, chloroacetyl, butoxycarbonyl, cyclopropylcarbonyl, cyclohexylcarbonyl, benzoyl, trimethoxybenzoyl, chlorobenzoyl or fluorobenzoylalkyl. 
     
     
       3. The compound defined in claim 2 which is 2-phenyl-5-acetyl-4,6,7,8-tetrahydrofuro[3,2-c]azepine. 
     
     
       4. The compound defined in claim 2 which is 2-phenyl-5-[3-(p-fluorobenzoyl)propyl]-4,6,7,8-tetrahydrofuro[3,2-c]azepine; and a physiologically tolerable acid addition salt thereof.