Nanofiber scaffold and manufacturing device, manufacturing method and application thereof

Abstract

An anofiber scaffold manufacturing device, suitable for manufacturing a nanofiber scaffold. The nanofiber scaffold manufacturing device includes a feeder, a delivery tube, a spinning assembly, an automatic collection device, and an electrostatic generator. The feeder is suitable for storing a spinning raw material. The delivery tube has an input end and an output end. The input end is connected to the feeder. The spinning assembly includes a spinning electrode and a nozzle. The nozzle is connected to the spinning electrode, and the spinning assembly is connected to the output end of the delivery tube. The automatic collection device is disposed opposite to the spinning assembly. The electrostatic generator is connected to the spinning electrode and forming an electric field between the spinning electrode and the automatic collection device. A nanofiber scaffold manufacturing method, a nanofiber scaffold, and an application thereof are also provided.

What is claimed is: 
     
         1 . A nanofiber scaffold manufacturing device, suitable for manufacturing a nanofiber scaffold, the nanofiber scaffold manufacturing device comprising:
 a feeder, suitable for storing a spinning raw material;   at least one delivery tube, having an input end and an output end, wherein the input end is connected to the feeder;   a spinning assembly, comprising a spinning electrode and at least one nozzle, wherein the at least one nozzle is connected to the spinning electrode, and the spinning assembly is connected to the output end of the delivery tube;   an automatic collection device, disposed opposite to the spinning assembly; and   an electrostatic generator, connected to the spinning electrode and forming an electric field between the spinning electrode and the automatic collection device.   
     
     
         2 . The nanofiber scaffold manufacturing device according to  claim 1 , further comprising a movement control unit, wherein the movement control unit comprises a carrier seat, a first axis, and a first motor, the spinning assembly is disposed on the carrier seat, the carrier seat is movably connected to the first axis, and the first motor is suitable for driving the carrier seat to move along an axial direction of the first axis. 
     
     
         3 . The nanofiber scaffold manufacturing device according to  claim 2 , wherein the movement control unit further comprises a second axis and a second motor, the axial direction of the first axis and an axial direction of the second axis are perpendicular to each other, the first axis is movably connected to the second axis, and the second motor is suitable for driving the first axis to move along the axial direction of the second axis. 
     
     
         4 . The nanofiber scaffold manufacturing device according to  claim 3 , wherein the movement control unit further comprises a third axis and a third motor, the axial direction of the first axis, the axial direction of the second axis, and an axial direction of the third axis are perpendicular to each other, the second axis is movably connected to the third axis, and the third motor is suitable for driving the second axis to move along the axial direction of the third axis. 
     
     
         5 . The nanofiber scaffold manufacturing device according to  claim 1 , further comprising a housing and a temperature-humidity control device, wherein the housing forms a spinning chamber, wherein the delivery tube, the spinning assembly, and the automatic collection device are disposed in the spinning chamber, and the temperature-humidity control device is suitable for detecting and controlling the temperature and humidity of the spinning chamber. 
     
     
         6 . The nanofiber scaffold manufacturing device according to  claim 5 , wherein the temperature-humidity control device comprises a hot and cold air fan, and the hot and cold air fan is suitable for providing cold air or hot air to the spinning chamber to control the temperature and humidity of the spinning chamber. 
     
     
         7 . The nanofiber scaffold manufacturing device according to  claim 1 , wherein the automatic collection device comprises a conveyor belt and at least two rollers, the conveyor belt is sleeved on the at least two rollers, and the at least two rollers rotate around their respective axes and drive the conveyor belt. 
     
     
         8 . The nanofiber scaffold manufacturing device according to  claim 7 , wherein the conveyor belt is a metal track. 
     
     
         9 . The nanofiber scaffold manufacturing device according to  claim 1 , further comprising a collection barrel, wherein the collection barrel is disposed on one side of the automatic collection device, and the collection barrel is suitable for collecting the nanofiber scaffold. 
     
     
         10 . The nanofiber scaffold manufacturing device according to  claim 1 , wherein the at least one nozzle is a needleless nozzle. 
     
     
         11 . The nanofiber scaffold manufacturing device according to  claim 1 , wherein the spinning electrode is a trough-type electrode. 
     
     
         12 . A nanofiber scaffold manufacturing method, comprising:
 providing a nanofiber scaffold manufacturing device, comprising:
 a feeder, suitable for storing a spinning raw material; 
 at least one delivery tube, having an input end and an output end, wherein the input end is connected to the feeder; 
 a spinning assembly, comprising a spinning electrode and at least one nozzle, wherein the at least one nozzle is connected to the spinning electrode, and the spinning assembly is connected to the output end of the delivery tube; 
 an automatic collection device, disposed opposite to the spinning assembly; and 
 an electrostatic generator, connected to the spinning electrode and forming an electric field between the spinning electrode and the automatic collection device; 
   using a polymer to prepare a polymer solution;   adding at least one of an inorganic substance or a drug to the polymer solution to form a spinning raw material;   controlling a temperature and humidity of the spinning chamber;   storing the spinning raw material in the feeder, and transporting the spinning raw material to the spinning assembly through the delivery tube;   turning on the electrostatic generator to form an electric field between the spinning electrode and the automatic collection device; and   ejecting the spinning raw material by the at least one nozzle and receiving the ejected spinning raw material by the automatic collection device to form a nanofiber scaffold.   
     
     
         13 . The nanofiber scaffold manufacturing method according to  claim 12 , wherein, in the spinning raw material, a concentration of the polymer is between 0.01 g/L and 100 g/L, and the polymer is selected from at least one of gelatin, collagen, hyaluronic acid, alginate, chitosan, polyethylene, polystyrene, styrene-butadiene rubber, styrene-isoprene rubber, polyester fiber, nylon fiber, epoxy resin, phenolic resin, and derivatives thereof. 
     
     
         14 . The nanofiber scaffold manufacturing method according to  claim 12 , wherein, in the spinning raw material, a concentration of at least one of the inorganic substance or the drug is between 0.01 g/L and 100 g/L, and the inorganic substance is selected from at least one of calcium, phosphorus, sodium, potassium, magnesium, sulfur, chlorine, copper, iodine, manganese, zinc, iron, carbon oxides, carbonates, and cyanide, or the drug is selected from at least one of insulin, growth factors, metformin, and bisphosphate drugs. 
     
     
         15 . The nanofiber scaffold manufacturing method according to  claim 12 , further comprising setting an injection flow rate of the at least one nozzle between 0.01 mL/s and 1 L/s. 
     
     
         16 . The nanofiber scaffold manufacturing method according to  claim 12 , wherein the electric field is between 1 μV/m and 1000 kV/m. 
     
     
         17 . The nanofiber scaffold manufacturing method according to  claim 12 , wherein, after adding at least one of the inorganic substance or the drug to the polymer solution, the polymer solution is stirred continuously for 1 to 96 hours. 
     
     
         18 . The nanofiber scaffold manufacturing method according to  claim 12 , wherein the temperature inside the spinning chamber is between 0° C. and 100° C. 
     
     
         19 . A nanofiber scaffold manufactured by the nanofiber scaffold manufacturing method according to  claim 1 , wherein the nanofiber scaffold comprises a polymer and an inorganic substance or a drug, the polymer is selected from at least one of gelatin, collagen, hyaluronic acid, alginate, chitosan, polyethylene, polystyrene, styrene-butadiene rubber, styrene-isoprene rubber, polyester fiber, nylon fiber, epoxy resin, phenolic resin, and derivatives thereof, the inorganic substance is selected from at least one of calcium, phosphorus, sodium, potassium, magnesium, sulfur, chlorine, copper, iodine, manganese, zinc, iron, carbon oxides, carbonates, and cyanide, and the drug is selected from insulin, growth factors, metformin, and bisphosphate drugs.