Systems and methods for adjusting appearance of objects in medical images

Abstract

Disclosed herein are systems and methods for adjusting appearance of objects in medical images.

What is claimed is: 
     
         1 . A method for adjusting appearance of objects in medical images, the method comprising:
 providing a computer wherein the computer receives a baseline image of a subject containing one or more objects, the baseline image taken with a baseline image quality and a baseline radiation dosage, and wherein the computer further receives an overlay image of the subject containing the one or more objects, the overlay image taken with an overlay image quality and an overlay radiation dosage:   generating, by the computer, a difference image of the baseline image and the overlay image:   generating, by the computer, a smoothed weight mask, wherein each pixel of the smoothed weight mask is a weighting; and   generating, by the computer, a composite image of the baseline image and the overlay image with contribution of the baseline image and the overlay image determined by the smoothed weight mask,   wherein the smoothed weight mask includes using soft weight values to construct a hybrid image, wherein the hybrid image is based on whether each pixel is above or below a defined cutoff value.   
     
     
         2 . The method of  claim 1 , wherein the overlay image quality is lower than the baseline image quality. 
     
     
         3 . The method of  claim 1 , wherein a first signal to noise ratio of the overlay image is lower than a second signal to noise ratio of the baseline image. 
     
     
         4 . The method of  claim 1 , further comprising performing image equalization of the baseline image and the overlay image by using a linear transformation determined by a scaling factor and an offset. 
     
     
         5 . The method of  claim 1 , wherein the difference image is obtained by subtracting the overlay image from the baseline image. 
     
     
         6 . The method of  claim 1 , wherein the weighting is determined by intensity of a corresponding pixel in the difference image, estimated intensity of background pixels in the difference image, and estimated intensity of one or more objects in the difference image, or a combination thereof. 
     
     
         7 . A method for adjusting appearance of objects in medical images, the method comprising:
 receiving, by a computer, a baseline image of a subject containing one or more objects:   receiving, by the computer, an overlay image of the subject containing the one or more objects:   transforming, the baseline image using a spatial transformation thereby generating a transformed baseline image:   rescaling, by the computer, the overlay image using a scaling factor and an offset thereby generating a resealed overlay image:   generating, by the computer, a difference image of the transformed baseline image and the rescaled overlay image:   generating, by the computer, a smoothed weight mask, wherein each pixel of the smoothed weight mask is a weighting; and   generating, by the computer, a composite image of the baseline image and the overlay image with contribution of the baseline image and the overlay image determined by the smoothed weight mask,   wherein the smoothed weight mask includes using soft weight values to construct a hybrid image.   
     
     
         8 . The method of  claim 7 , wherein the overlay image quality is lower than the baseline image quality. 
     
     
         9 . The method of  claim 7 , wherein a first signal to noise ratio of the overlay image is lower than a second signal to noise ratio of the baseline image. 
     
     
         10 . The method of  claim 7 , further comprising performing image equalization of the baseline image and the overlay image by using a linear transformation determined by a scaling factor and an offset. 
     
     
         11 . The method of  claim 7 , wherein the difference image is obtained by subtracting the rescaled overlay image from the transformed baseline image. 
     
     
         12 . The method of  claim 7 , wherein the weighting is determined by intensity of a corresponding pixel in the difference image, estimated intensity of background pixels in the difference image, and estimated intensity of objects in the difference image, or a combination thereof.