Resin, adsorption material, and method of lowering ldl-c concentration in blood

Abstract

A resin is formed through a ring-opening reaction of dextran sulfate sodium salt and a modified polyether sulfone. The modified polyether sulfone is formed by a reaction of polyether sulfone and an epoxy compound containing a carbon-carbon double bond. The resin may serve as an adsorption material, which can be a porous film or a porous hollow fiber. The adsorption material can be in contact with blood to lower LDL-C concentration in the blood.

What is claimed is: 
     
         1 . A resin, formed through a ring-opening reaction of dextran sulfate sodium salt and a modified polyether sulfone,
 wherein the modified polyether sulfone is formed by a reaction of polyether sulfone and an epoxy compound containing a carbon-carbon double bond.   
     
     
         2 . The resin as claimed in  claim 1 , wherein the polyether sulfone and the epoxy compound containing a carbon-carbon double bond have a weight ratio of 100:20 to 100:30. 
     
     
         3 . The resin as claimed in  claim 1 , wherein the modified polyether sulfone and the dextran sulfate sodium salt have a weight ratio of 100:1 to 100:1500. 
     
     
         4 . The resin as claimed in  claim 1 , wherein a repeating unit of the polyether sulfone is 
       
         
           
           
               
               
           
         
       
       or a combination thereof. 
     
     
         5 . The resin as claimed in  claim 1 , wherein the polyether sulfone has a weight average molecular weight of 55,000 g/mol to 75,000 g/mol. 
     
     
         6 . The resin as claimed in  claim 1 , wherein the dextran sulfate sodium salt has a weight average molecular weight of 5000 g/mol to 10000 g/mol. 
     
     
         7 . The resin as claimed in  claim 1 , wherein the epoxy compound containing a carbon-carbon double bond is 
       
         
           
           
               
               
           
         
       
       or a combination thereof. 
     
     
         8 . An adsorption material, comprising the resin as claimed in  claim 1 ,
 wherein the adsorption material is in a form of a porous film or a porous hollow fiber.   
     
     
         9 . The adsorption material as claimed in  claim 8 , wherein the adsorption material has a porosity of 60% to 90%. 
     
     
         10 . The adsorption material as claimed in  claim 8 , wherein the porous film has a thickness of 20 micrometers to 60 micrometers. 
     
     
         11 . The adsorption material as claimed in  claim 8 , wherein the porous hollow fiber has an inner diameter of 300 micrometers to 600 micrometers, and the porous hollow fiber has a thickness of 80 micrometers to 150 micrometers. 
     
     
         12 . A method of lowering low-density lipoprotein cholesterol concentration in blood, comprising:
 bringing blood into contact with the adsorption material as claimed in  claim 8  to lower low-density lipoprotein cholesterol concentration in the blood.