Devices, systems and methods for personalized neuromodulation

Abstract

A system for personalized neuromodulation includes a neuroimaging recording device including sensors for detecting neural activity in a patient. An optimization module determines a personalized neuromodulation treatment protocol for the patient. The optimization module includes a neuromodulation target optimization module for determining neural targets in the patient for the personalized neuromodulation treatment protocol. The optimization module includes a neuromodulation parameters optimization module for determining optimized neural stimulation parameters for the personalized neuromodulation treatment protocol. A personalized neural stimulation device receives the neural targets from the neuromodulation target optimization module and receives the optimized neural stimulation parameters from the neuromodulation parameters optimization module. The personalized neural stimulation device delivers the personalized neuromodulation treatment protocol to the patient. The personalized neural stimulation device includes at least one neural stimulation device for stimulating the targets in the patient. A neuroimaging navigation system determines a placement of the neural stimulation device(s) about the patient.

What is claimed is: 
     
         1 . A system for personalized neuromodulation, comprising:
 a neuroimaging recording device including a plurality of sensors configured to detect neural activity in a patient;   an optimization module configured to receive neural activity data from the neuroimaging recording device and determine a personalized neuromodulation treatment protocol for the patient, the optimization module including:
 a neuromodulation target optimization module configured to determine at least one neural target in the patient for the personalized neuromodulation treatment protocol; and 
 a neuromodulation parameters optimization module configured to determine optimized neural stimulation parameters for the personalized neuromodulation treatment protocol; and 
   a personalized neural stimulation device configured to receive the at least one neural target from the neuromodulation target optimization module and to receive the optimized neural stimulation parameters from the neuromodulation parameters optimization module,   the personalized neural stimulation device configured to deliver the personalized neuromodulation treatment protocol to the patient, the personalized neural stimulation device including:
 a neural stimulation device configured to stimulate the at least one target in the patient; and 
 a neuroimaging navigation system configured to determine a placement of the at least one neural stimulation device about the patient. 
   
     
     
         2 . The system for personalized neuromodulation of  claim 1 , wherein the neural stimulation device includes a transcranial stimulation device. 
     
     
         3 . The system for personalized neuromodulation of  claim 1 , wherein the neural stimulation device is a transcranial magnetic stimulator (TMS), a transcranial direct current stimulator (tDCS), a transcranial electrical stimulator (tES), a transcranial focused ultrasound (tFUS), a deep brain stimulator (DBS), a intracranial cortical stimulation (ICS), a pressure/mechanical wave (shock wave) stimulator, a micro-scale magnetic fields stimulator, an optogenetics stimulator, or a photobiomodulation stimulator. 
     
     
         4 . The system for personalized neuromodulation of  claim 1 , wherein the neuroimaging recording device is an electroencephalogram (EEG) system, a functional magnetic resonance imaging (fMRI) system, a diffusion tensor imaging (DTI) system, a positron emission tomography (PET) system, a magnetic resonance spectroscopy (MRS), a Single-photon emission computed tomography (SPECT) system, a functional ultrasound imaging (fUS) system, a computer tomography (CT) system, a functional near-infrared spectroscopy (fNIRS) system, or a magnetoencephalography (MEG) system. 
     
     
         5 . The system for personalized neuromodulation of  claim 1 , wherein the neuroimaging recording device includes wired EEG sensors. 
     
     
         6 . The system for personalized neuromodulation of  claim 1 , wherein the neuroimaging recording device includes wireless EEG sensors 
     
     
         7 . A method of personalized neuromodulation, comprising:
 detecting, by a neuroimaging recording device including a plurality of sensors, neural activity in a patient;   determining, by an optimization module, a personalized neuromodulation treatment protocol for the patient using the detected neural activity in the patient, wherein determining the personalized neuromodulation treatment protocol includes:
 determining, by a neuromodulation target optimization module, at least one neural target in the patient for the personalized neuromodulation treatment protocol; and 
 determining, by a neuromodulation parameters optimization module, optimized neural stimulation parameters for the personalized neuromodulation treatment protocol; 
   receiving, at a personalized neural stimulation device, the at least one neural target from the neuromodulation target optimization module and the optimized neural stimulation parameters from the neuromodulation parameters optimization module of the neuromodulation treatment protocol; and   delivering, by the personalized neural stimulation device, the neuromodulation treatment protocol to the patient.   
     
     
         8 . The method of personalized neuromodulation of  claim 7 , wherein the personalized neural stimulation device includes a neural stimulation device configured to stimulate the at least one target in the patient; and wherein a placement of the neural stimulation device is determined by a neuroimaging navigation system configured to determine a placement of the at least one neural stimulation device about the patient. 
     
     
         9 . The method of personalized neuromodulation of  claim 8 , wherein the neural stimulation device includes a transcranial stimulation device positioned about the patient. 
     
     
         10 . The method of personalized neuromodulation of  claim 8 , wherein the neural stimulation device includes a transcranial magnetic stimulator (TMS), a transcranial direct current stimulator (tDCS), a transcranial electrical stimulator (tES), a transcranial focused ultrasound (tFUS), a deep brain stimulator (DBS), a intracranial cortical stimulation (ICS), a pressure/mechanical wave (shock wave) stimulator, a micro-scale magnetic fields stimulator, an optogenetics stimulator, or a photobiomodulation stimulator positioned about the patient. 
     
     
         11 . The method of personalized neuromodulation of  claim 7 , wherein the neuroimaging recording device includes an electroencephalogram (EEG) system, a functional magnetic resonance imaging (fMRI) system, a diffusion tensor imaging (DTI) system, a positron emission tomography (PET) system, a magnetic resonance spectroscopy (MRS), a Single-photon emission computed tomography (SPECT) system, a functional ultrasound imaging (fUS) system, a computer tomography (CT) system, a functional near-infrared spectroscopy (fNIRS) system, or a magnetoencephalography (MEG) system. 
     
     
         12 . The method of personalized neuromodulation of  claim 7 , wherein the neuroimaging recording device includes wired EEG sensors positioned about the patient. 
     
     
         13 . The method of personalized neuromodulation of  claim 7 , wherein the neuroimaging recording device includes wireless EEG sensors positioned about the patient. 
     
     
         14 . The method of personalized neuromodulation of  claim 7 , wherein the optimized neural stimulation parameters are updated iteratively. 
     
     
         15 . A computer program product comprising a non-transitory computer readable storage medium having program instructions embodied therewith, the program instructions executable by a processor to cause the processor to:
 detect, by a neuroimaging recording device including a plurality of sensors, neural activity in a patient;   determine, by an optimization module, a personalized neuromodulation treatment protocol for the patient using the detected neural activity in the patient, wherein determining the personalized neuromodulation treatment protocol includes:
 determining, by a neuromodulation target optimization module, at least one neural target in the patient for the personalized neuromodulation treatment protocol; and 
 determining, by a neuromodulation parameters optimization module, optimized neural stimulation parameters for the personalized neuromodulation treatment protocol; 
   receive, at a personalized neural stimulation device, the at least one neural target from the neuromodulation target optimization module and the optimized neural stimulation parameters from the neuromodulation parameters optimization module of the neuromodulation treatment protocol; and   deliver, by the personalized neural stimulation device, the neuromodulation treatment protocol to the patient.