Nicotine pouch filler and method of preparing the same

Abstract

Provided is a nicotine pouch filler including nicotine, a release control excipient including at least one or more selected from a group consisting of cellulose and sugar alcohol, a binder, a pH adjuster, and a flavoring agent, in which the release control excipient includes cellulose and sugar alcohol, the cellulose and the sugar alcohol are mixed at a weight ratio of 1:9 to 5:5, the cellulose includes one or more of microcrystalline cellulose (MCC) and methyl cellulose, and the sugar alcohol includes at least one or more selected from a group consisting of erythritol, xylitol, mannitol, sorbitol, maltitol, and isomaltol.

What is claimed is: 
     
         1 . A nicotine pouch filler comprising:
 nicotine;   a release control excipient;   a binder;   a pH adjuster; and   a flavoring agent,   wherein the release control excipient comprises cellulose and sugar alcohol,   wherein the cellulose and the sugar alcohol are mixed at a weight ratio of 1:9 to 5:5,   wherein the cellulose comprises one or more of microcrystalline cellulose and methyl cellulose, and   wherein the sugar alcohol comprises at least one or more selected from a group consisting of erythritol, xylitol, mannitol, sorbitol, maltitol, and isomaltol.   
     
     
         2 . The nicotine pouch filler of  claim 1 , wherein the cellulose is microcrystalline cellulose. 
     
     
         3 . The nicotine pouch filler of  claim 1 , wherein a content of the cellulose is 10 to 30 wt % with respect to a weight of total solid contents of the nicotine pouch filler. 
     
     
         4 . The nicotine pouch filler of  claim 1 , wherein a content of the sugar alcohol is 45 to 65 wt % with respect to a weight of total solid contents of the nicotine pouch filler. 
     
     
         5 . The nicotine pouch filler of  claim 1 , wherein
 the nicotine comprises nicotine salt, and   the nicotine salt comprises at least one or more selected from a group consisting of nicotine salt benzoate, nicotine salt tartrate, nicotine salt malate, and nicotine salt salicylate.   
     
     
         6 . The nicotine pouch filler of  claim 1 , wherein the nicotine is contained in the cellulose. 
     
     
         7 . The nicotine pouch filler of  claim 1 , wherein
 the binder comprises at least one or more selected from a group consisting of Povidone K-25, hydroxypropyl cellulose, low-substituted hydroxypropyl cellulose, hydroxypropylmethyl cellulose (HPMC), and carboxymethylcellulose (CMC), and   a content of the binder is 10 wt % or less with respect to a weight of total solid contents of the nicotine pouch filler.   
     
     
         8 . The nicotine pouch filler of  claim 1 , wherein the pH adjuster comprises at least one or more selected from a group consisting of sodium bicarbonate and sodium carbonate. 
     
     
         9 . The nicotine pouch filler of  claim 8 , wherein
 the pH adjuster comprises sodium bicarbonate and sodium carbonate, and   a weight ratio of the sodium bicarbonate and the sodium carbonate is 7:3 to 6:4.   
     
     
         10 . The nicotine pouch filler of  claim 1 , wherein pH of the nicotine pouch filler is 7.0 to 8.8. 
     
     
         11 . The nicotine pouch filler of  claim 1 , wherein the nicotine pouch filler comprises particles with a size of 150 to 300 μm. 
     
     
         12 . The nicotine pouch filler of  claim 1 , wherein the nicotine pouch filler has a content of moisture of 5% or less. 
     
     
         13 . The nicotine pouch filler of  claim 1 , wherein the nicotine pouch filler has nicotine elution performance of 10% or more within 4 minutes, and nicotine elution performance of 50% to 70% within 16 minutes. 
     
     
         14 . A nicotine pouch comprising:
 a nicotine pouch filler; and   a packaging material,   wherein the nicotine pouch filler comprises:
 nicotine; 
 a release control excipient; 
 a binder; 
 a pH adjuster; and 
 a flavoring agent, 
   wherein the release control excipient comprises cellulose and sugar alcohol,   wherein the cellulose and the sugar alcohol are mixed at a weight ratio of 1:9 to 5:5,   wherein the cellulose comprises one or more of microcrystalline cellulose and methyl cellulose, and   wherein the sugar alcohol comprises at least one or more selected from a group consisting of erythritol, xylitol, mannitol, sorbitol, maltitol, and isomaltol.   
     
     
         15 . A method of preparing a nicotine pouch filler, the method comprising:
 step S1 of mixing at least one or more selected from a group consisting of nicotine, a release control excipient, a binder, a pH adjuster, and a flavoring agent;   step S2 of spraying a solvent; and   step S3 of performing granulation,   wherein, in step S1, the release control excipient comprises cellulose and sugar alcohol,   wherein the cellulose and the sugar alcohol are mixed at a weight ratio of 1:9 to 5:5,   wherein the cellulose comprises one or more of microcrystalline cellulose and methyl cellulose, and   wherein the sugar alcohol comprises at least one or more selected from a group consisting of erythritol, xylitol, mannitol, sorbitol, maltitol, and isomaltol.