Composition for obtaining a material for tissue regeneration or reconstruction, for example of bone tissue, or drug delivery, as well as the system and method for creating such composition

Abstract

The present invention relates to a composition for obtaining a tissue regeneration or reconstruction material, for example bone tissue, or a material capable of transporting and/or releasing at least one pharmaceutical, nutraceutical and/or cosmeceutical active ingredient.

1 . A composition for obtaining a tissue regeneration or reconstruction material, for example bone tissue, or a material capable of transporting and/or releasing at least one pharmaceutical, nutraceutical and/or cosmeceutical active ingredient, comprising at least one first element containing at least two carboxyl endings (—COOH) and at least one second element containing at least two alcoholic endings (—OH), wherein said composition includes zirconium, said zirconium constituting among 5 and 20% by weight of said composition. 
     
     
         2 . The composition according to  claim 1 , wherein said at least one first element is selected from the group consisting of citric acid, aconitic acid, malic acid, maleic acid, malonic acid, adipic acid, succinic acid, suberic acid or mixtures thereof. 
     
     
         3 . The composition according to  claim 1 , wherein said at least one second element consists of a diol, a triol, a polyphenol or mixtures thereof. 
     
     
         4 . The composition according to  claim 3 , wherein said at least one second element consists of glycerol, 1,8-octanediol, 1,12-dodecanediol, propylene glycol, at least one alditol, gluconic acid, tannic acid or mixtures thereof. 
     
     
         5 . The composition according to  claim 1 , wherein said at least one first element consists of citric acid and said at least one second element consists of glycerol. 
     
     
         6 . The composition according to  claim 1 , consisting of a polyester. 
     
     
         7 . The composition according to  claim 1 , impregnated with pharmaceutical, nutraceutical, cosmeceutical active ingredients, or with at least one molecule for carrying out an antibacterial and/or antiproliferative activity. 
     
     
         8 . The composition according to  claim 1 , wherein said zirconium constitutes among 10 and 15% by weight of the composition. 
     
     
         9 . A system comprising or consisting of three components for obtaining, when mixed together, a composition for obtaining a tissue regeneration or reconstruction material, for example bone tissue, or a material capable of transporting and/or releasing at least one pharmaceutical, nutraceutical and/or cosmeceutical active ingredient, wherein:
 a first component of said at least three components comprises or consists of at least one first element containing at least two carboxyl endings (—COOH),   a second component of said at least three components comprises or consists of at least one second element containing at least two alcoholic endings (—OH),   a third component of said at least three components comprises or consists of zirconium,   where the molar ratio between zirconium and the first element is between 0.1 and 0.5.   
     
     
         10 . The system according to  claim 9 , wherein said at least one first element is selected from the group consisting of citric acid, aconitic acid, malic acid, maleic acid, malonic acid, adipic acid, succinic acid, suberic acid or mixtures thereof. 
     
     
         11 . The system according to  claim 9 , wherein said at least one second element consists of a diol, a triol, a polyphenol, such as for example glycerol, 1,8-octanediol, 1,12-dodecanediol, propylene glycol, at least one alditol, gluconic acid, tannic acid or mixtures thereof. 
     
     
         12 . The system according to  claim 9 , wherein said at least one first component comprises said at least one first element solubilized with a solvent selected from the group consisting of ethanol, methanol, propanol, isopropanol, longer chain alcohols or mixtures thereof. 
     
     
         13 . The system according to  claim 9 , wherein said zirconium comprises or consists of zirconium propoxide. 
     
     
         14 . The system according to  claim 9 , wherein said third component comprises zirconium mixed with a solvent selected from the group consisting of ethanol, methanol, propanol, isopropanol, longer chain alcohols or mixtures thereof. 
     
     
         15 . The system according to  claim 9 , wherein said second component comprises said at least one second element mixed up to homogeneity with a solvent selected from the group consisting of ethanol, methanol, propanol, isopropanol, longer chain alcohols or their blends. 
     
     
         16 . The system according to  claim 9 , wherein the molar ratio between zirconium and first element is between 0.35 and 0.4. 
     
     
         17 . The system according to  claim 9 , wherein the molar ratio between the first and second element is between 1 and 3. 
     
     
         18 . The system according to  claim 9 , wherein the molar ratio between the first and the second element is between 1.8 and 2.2. 
     
     
         19 . A process for obtaining a composition for obtaining a tissue regeneration or reconstruction material or a material capable of transporting and/or releasing at least one pharmaceutical, nutraceutical and/or cosmeceutical active ingredient, by means of the system according to  claim 9 , wherein said first component and said third component are first mixed, after which, following the formation of the third-first component solution, the second component is introduced and then it is heated so as to obtain a polymer or a polyester. 
     
     
         20 . The process according to  claim 19 , wherein a solution of said first element in a solvent is first mixed with said zirconium, thereby obtaining a stable and homogeneous solution after heating between 40° C. and 100° C. and then one proceeds to introduce the second component. 
     
     
         21 . A composition for the use in the treatment of tissue regeneration or reconstruction, for example of bone tissue, or as a material capable of transporting and/or releasing at least one pharmaceutical, nutraceutical, cosmeceutical active ingredient, or in any case for diagnostic and/or theranostics purposes in the biomedical field, such as regenerative and reconstructive tissue engineering if desired for cardiovascular, muscular, epidermis/skin or nervous system applications, said composition being according to  claim 1 .