Altering cancer cellular functions through proton mopping

Abstract

Proton mopping is a new anti-cancer therapeutic approach that disrupts cancer's immunologic balance. It results in the alteration of the pHi/pHe ratio (intracellular-extracellular) of the cancer cell, leading cancer to either normalcy or apoptosis. This technology deploys a chemical compound that has two parts, a glucose part to guide the molecule to the cancer site and a proton neutralizer to mop up the protons. Proof of the validity of this therapeutic approach came after using an existing chemical compound 2-[2(2-Aminoethoxy)ethoxy]ethyl a-D-mannopyranoside, C 12 H 25 NO 8 , which has the above mentioned properties. This compound is of the class of functionalized PEGylated glycosides, which are ligands for conjugation to biological molecules.

1 . A cancer therapeutic method comprising administering a proton (hydrogen ion) mopping compound to a subject. 
     
     
         2 . A proton mopping compound for use in cancer therapy. 
     
     
         3 . The compound of  claim 2 , wherein said compound has two parts, one for targeting cancer cells and one for mopping up the protons. 
     
     
         4 . The compound of  claim 2 , comprising a targeting part that is a member of the glucose family or equivalent or analog to glucose. 
     
     
         5 . The compound of  claim 2  further comprising a proton mopping part that is a member of the amine NH2 family or equivalent proton acceptor. 
     
     
         6 . The compound of  claim 2 , which enters cancer cells and mops up excess protons (hydrogen ions) produced by cancer metabolism. 
     
     
         7 . The compound of  claim 2 , which alters the pH ratio between the intracellular and the extracellular space of cancer cells. 
     
     
         8 . The compound of  claim 2 , which alters cancer metabolism by altering cancer cell pHi/pHe (intra-extracellular), thereby guiding cancer cells to either normalcy or apoptosis. 
     
     
         9 . The method of  claim 1 , wherein said compound has molecular formula C12H2sNOs and name 2-[2(2-Aminoethoxy)ethoxy]ethyl a-D-mannopyranoside.