New synergistic combinations based on fenm and an acetylcholinesterase inhibitor

Abstract

The invention relates to a composition comprising a synergistic combination of fluoroethylnormemantine (FENM) and at least one acetylcholinesterase inhibitor. More particularly, the invention relates to said composition for use thereof as a drug, even more particularly for use thereof in the treatment of a pathology selected from among tauopathies, synucleinopathies, amyloidopathies, Alzheimer's disease, Parkinson's disease, multiple system atrophy, Huntington's disease, posterior cortical atrophy, Pick's disease, epilepsy, vascular dementia, frontotemporal dementia, dementia with Lewy bodies, amyotrophic lateral sclerosis.

1 . A composition comprising a synergistic combination of 3-(2-fluoroethyl) adamantan-1-amine (FENM) or any one of its pharmaceutically-acceptable salts and at least one acetylcholinesterase inhibitor or any one of its pharmaceutically-acceptable salts. 
     
     
         2 . The composition according to  claim 1 , wherein said at least one acetylcholine esterase inhibitor is selected from among donepezil, galantamine, rivastigmine, tacrine, or any one of their pharmaceutically-acceptable salts. 
     
     
         3 . The composition according to  claim 1 , wherein the FENM dose is compatible with a FENM dose less than or equal to 20 mg/day. 
     
     
         4 . The composition according to  claim 1 , wherein said at least one acetylcholinesterase inhibitor is donepezil which is present at a dose compatible with a dosage less than or equal to 10 mg/day. 
     
     
         5 . The composition according to  claim 1 , wherein said at least one acetylcholinesterase inhibitor is the rivastigmine which is present at a dose compatible with a dosage less than or equal to 3 mg/day. 
     
     
         6 . The composition according to  claim 1 , wherein said at least one acetylcholinesterase inhibitor is galantamine which is present at a dose compatible with a dosage less than or equal to 16 mg/day. 
     
     
         7 . The composition according to  claim 1 , wherein the FENM/at least one acetylcholine esterase inhibitor molar ratio is less than or equal to 4. 
     
     
         8 . A pharmaceutical composition comprising the composition according to  claim 1  and one or more suitable excipients. 
     
     
         9 . A method of treating a pathology selected from among tauopathies, synucleinopathies, amyloidopathies, Alzheimer's disease, Parkinson's disease, multiple system atrophy, Huntington's disease, posterior cortical atrophy, Pick's disease, epilepsy, vascular dementia, frontotemporal dementia, dementia with Lewy bodies, amyotrophic lateral sclerosis comprising administering, to a subject in need thereof, an effective amount of the composition according to  claim 1 . 
     
     
         10 . A method of treating a pathology selected from among tauopathies, synucleinopathies, amyloidopathies, Alzheimer's disease, Parkinson's disease, multiple system atrophy, Huntington disease, posterior cortical atrophy, Pick's disease, epilepsy, vascular dementia, frontotemporal dementia, dementia with Lewy bodies, amyotrophic lateral sclerosis, comprising:
 administering to a subject in need thereof, an effective amount of 3-(2-fluoroethyl) adamantan-1-amine (FENM), or a pharmaceutically-acceptable salt thereof, in synergistic combination with at least one acetylcholinesterase inhibitor selected from among donepezil, galantamine, rivastigmine, tacrine, or any one of their pharmaceutically-acceptable salts.   
     
     
         11 . The composition according to  claim 7 , wherein the FENM/at least one acetylcholine esterase inhibitor molar ratio is less than or equal to 3. 
     
     
         12 . The composition according to  claim 11 , wherein the FENM/at least one acetylcholine esterase inhibitor molar ratio is less than or equal to 2. 
     
     
         13 . The composition according to  claim 12 , wherein the FENM/at least one acetylcholine esterase inhibitor molar ratio is less than or equal to 1.