US2024415884A1PendingUtilityA1

Molecules that bind to cd276 polypeptides

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Assignee: UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATIONPriority: Feb 1, 2022Filed: Jan 31, 2023Published: Dec 19, 2024
Est. expiryFeb 1, 2042(~15.5 yrs left)· nominal 20-yr term from priority
Inventors:Dimiter S. DimitrovXianglei LiuWei LiJohn W. MellorsDusan BaekZehua Sun
A61K 40/421A61K 40/31A61K 40/11A61K 40/4224C07K 2317/56C07K 16/2827A61K 45/06A61K 2239/17A61K 2239/21A61K 2239/13A61P 35/00C07K 2317/55C07K 2317/622C07K 2317/31C07K 16/2809C07K 2317/92A61K 35/17A61K 39/464411A61K 39/4631A61K 39/4611
60
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Claims

Abstract

This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, antibody domain, CAR, cell engager, and/or ADC) to a CD276 polypeptide. For example, binders (e.g., antibodies, antigen binding fragments, antibody domains, CARs, cell engagers, and/or ADCs) that bind to a CD276 polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having cancer are provided.

Claims

exact text as granted — not AI-modified
1 . An antibody comprising:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1 (or SEQ ID NO:1 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:2 (or SEQ ID NO:2 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:3 (or SEQ ID NO:3 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9 (or SEQ ID NO:9 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:10 (or SEQ ID NO:10 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:11 (or SEQ ID NO:11 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17 (or SEQ ID NO:17 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:18 (or SEQ ID NO:18 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:19 (or SEQ ID NO:19 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25 (or SEQ ID NO:25 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:26 (or SEQ ID NO:26 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:27 (or SEQ ID NO:27 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:33 (or SEQ ID NO:33 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:34 (or SEQ ID NO:34 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:35 (or SEQ ID NO:35 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:41 (or SEQ ID NO:41 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:42 (or SEQ ID NO:42 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:43 (or SEQ ID NO:43 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (vii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions);   (viii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:473 (or SEQ ID NO:473 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:474 (or SEQ ID NO:474 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:475 (or SEQ ID NO:475 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:481 (or SEQ ID NO:481 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:482 (or SEQ ID NO:482 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:483 (or SEQ ID NO:483 with one, two, or three amino acid additions, deletions, or substitutions);   (ix) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (x) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         2 - 22 . (canceled) 
     
     
         23 . An antigen binding fragment comprising:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1 (or SEQ ID NO:1 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:2 (or SEQ ID NO:2 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:3 (or SEQ ID NO:3 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9 (or SEQ ID NO:9 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:10 (or SEQ ID NO:10 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:11 (or SEQ ID NO:11 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17 (or SEQ ID NO:17 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:18 (or SEQ ID NO:18 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:19 (or SEQ ID NO:19 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25 (or SEQ ID NO:25 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:26 (or SEQ ID NO:26 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:27 (or SEQ ID NO:27 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:33 (or SEQ ID NO:33 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:34 (or SEQ ID NO:34 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:35 (or SEQ ID NO:35 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:41 (or SEQ ID NO:41 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:42 (or SEQ ID NO:42 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:43 (or SEQ ID NO:43 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (vii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions);   (viii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:473 (or SEQ ID NO:473 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:474 (or SEQ ID NO:474 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:475 (or SEQ ID NO:475 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:481 (or SEQ ID NO:481 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:482 (or SEQ ID NO:482 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:483 (or SEQ ID NO:483 with one, two, or three amino acid additions, deletions, or substitutions);   (ix) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (x) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         24 - 48 . (canceled) 
     
     
         49 . An antibody domain comprising:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions).   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         50 - 60 . (canceled) 
     
     
         61 . A chimeric antigen receptor comprising an antigen binding domain, a hinge, a transmembrane domain, and one or more signaling domains, wherein said antigen binding domain comprises an antibody, an antigen-binding fragment, or an antibody domain comprising:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1 (or SEQ ID NO:1 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:2 (or SEQ ID NO:2 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:3 (or SEQ ID NO:3 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9 (or SEQ ID NO:9 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:10 (or SEQ ID NO:10 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:11 (or SEQ ID NO:11 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17 (or SEQ ID NO:17 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:18 (or SEQ ID NO:18 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:19 (or SEQ ID NO:19 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25 (or SEQ ID NO:25 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:26 (or SEQ ID NO:26 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:27 (or SEQ ID NO:27 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:33 (or SEQ ID NO:33 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:34 (or SEQ ID NO:34 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:35 (or SEQ ID NO:35 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:41 (or SEQ ID NO:41 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:42 (or SEQ ID NO:42 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:43 (or SEQ ID NO:43 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (vii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions);   (viii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:473 (or SEQ ID NO:473 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:474 (or SEQ ID NO:474 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:475 (or SEQ ID NO:475 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:481 (or SEQ ID NO:481 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:482 (or SEQ ID NO:482 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:483 (or SEQ ID NO:483 with one, two, or three amino acid additions, deletions, or substitutions);   (ix) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (x) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         62 . The chimeric antigen receptor of  claim 61 , wherein said antigen binding domain comprises a scFv having the ability to bind to a CD276 polypeptide. 
     
     
         63 - 66 . (canceled) 
     
     
         67 . A cell comprising a chimeric antigen receptor of  claim 61 . 
     
     
         68 . The cell of  claim 67 , wherein said cell is a T cell, a stem cell, or an NK cell. 
     
     
         69 . A cell engager comprising a first antigen binding domain, a linker, and a second antigen binding domain, wherein said first antigen binding domain comprises an antibody, an antigen-binding fragment, or an antibody domain comprising:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1 (or SEQ ID NO:1 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:2 (or SEQ ID NO:2 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:3 (or SEQ ID NO:3 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9 (or SEQ ID NO:9 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:10 (or SEQ ID NO:10 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:11 (or SEQ ID NO:11 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17 (or SEQ ID NO:17 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:18 (or SEQ ID NO:18 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:19 (or SEQ ID NO:19 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25 (or SEQ ID NO:25 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:26 (or SEQ ID NO:26 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:27 (or SEQ ID NO:27 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:33 (or SEQ ID NO:33 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:34 (or SEQ ID NO:34 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:35 (or SEQ ID NO:35 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:41 (or SEQ ID NO:41 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:42 (or SEQ ID NO:42 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:43 (or SEQ ID NO:43 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (vii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions);   (viii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:473 (or SEQ ID NO:473 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:474 (or SEQ ID NO:474 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:475 (or SEQ ID NO:475 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:481 (or SEQ ID NO:481 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:482 (or SEQ ID NO:482 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:483 (or SEQ ID NO:483 with one, two, or three amino acid additions, deletions, or substitutions);   (ix) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (x) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         70 - 82 . (canceled) 
     
     
         83 . A nucleic acid comprising a nucleic acid sequence encoding at least part of an antibody, an antigen-binding fragment, or an antibody domain comprising:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1 (or SEQ ID NO:1 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:2 (or SEQ ID NO:2 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:3 (or SEQ ID NO:3 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9 (or SEQ ID NO:9 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:10 (or SEQ ID NO:10 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:11 (or SEQ ID NO:11 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17 (or SEQ ID NO:17 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:18 (or SEQ ID NO:18 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:19 (or SEQ ID NO:19 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25 (or SEQ ID NO:25 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:26 (or SEQ ID NO:26 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:27 (or SEQ ID NO:27 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:33 (or SEQ ID NO:33 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:34 (or SEQ ID NO:34 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:35 (or SEQ ID NO:35 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:41 (or SEQ ID NO:41 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:42 (or SEQ ID NO:42 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:43 (or SEQ ID NO:43 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (vii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions);   (viii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:473 (or SEQ ID NO:473 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:474 (or SEQ ID NO:474 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:475 (or SEQ ID NO:475 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:481 (or SEQ ID NO:481 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:482 (or SEQ ID NO:482 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:483 (or SEQ ID NO:483 with one, two, or three amino acid additions, deletions, or substitutions);   (ix) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (x) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         84 - 87 . (canceled) 
     
     
         88 . A nucleic acid comprising a nucleic acid sequence encoding a chimeric antigen receptor or a cell engager comprising:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1 (or SEQ ID NO:1 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:2 (or SEQ ID NO:2 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:3 (or SEQ ID NO:3 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9 (or SEQ ID NO:9 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:10 (or SEQ ID NO:10 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:11 (or SEQ ID NO:11 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17 (or SEQ ID NO:17 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:18 (or SEQ ID NO:18 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:19 (or SEQ ID NO:19 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25 (or SEQ ID NO:25 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:26 (or SEQ ID NO:26 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:27 (or SEQ ID NO:27 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:33 (or SEQ ID NO:33 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:34 (or SEQ ID NO:34 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:35 (or SEQ ID NO:35 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:41 (or SEQ ID NO:41 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:42 (or SEQ ID NO:42 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:43 (or SEQ ID NO:43 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (vii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions);   (viii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:473 (or SEQ ID NO:473 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:474 (or SEQ ID NO:474 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:475 (or SEQ ID NO:475 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:481 (or SEQ ID NO:481 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:482 (or SEQ ID NO:482 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:483 (or SEQ ID NO:483 with one, two, or three amino acid additions, deletions, or substitutions);   (ix) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (x) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         89 - 93 . (canceled) 
     
     
         94 . An antibody-drug conjugate (ADC) comprising an antigen binding domain covalently linked to a drug, wherein said antigen binding domain comprises an antibody, an antigen binding fragment, or an antibody domain comprising:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1 (or SEQ ID NO:1 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:2 (or SEQ ID NO:2 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:3 (or SEQ ID NO:3 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9 (or SEQ ID NO:9 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:10 (or SEQ ID NO:10 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:11 (or SEQ ID NO:11 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17 (or SEQ ID NO:17 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:18 (or SEQ ID NO:18 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:19 (or SEQ ID NO:19 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25 (or SEQ ID NO:25 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:26 (or SEQ ID NO:26 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:27 (or SEQ ID NO:27 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:33 (or SEQ ID NO:33 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:34 (or SEQ ID NO:34 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:35 (or SEQ ID NO:35 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:41 (or SEQ ID NO:41 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:42 (or SEQ ID NO:42 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:43 (or SEQ ID NO:43 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (vii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions);   (viii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:473 (or SEQ ID NO:473 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:474 (or SEQ ID NO:474 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:475 (or SEQ ID NO:475 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:481 (or SEQ ID NO:481 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:482 (or SEQ ID NO:482 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:483 (or SEQ ID NO:483 with one, two, or three amino acid additions, deletions, or substitutions);   (ix) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (x) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         95 - 97 . (canceled) 
     
     
         98 . A composition comprising an antibody, an antigen binding fragment, or an antibody domain comprising:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1 (or SEQ ID NO:1 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:2 (or SEQ ID NO:2 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:3 (or SEQ ID NO:3 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9 (or SEQ ID NO:9 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:10 (or SEQ ID NO:10 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:11 (or SEQ ID NO:11 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17 (or SEQ ID NO:17 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:18 (or SEQ ID NO:18 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:19 (or SEQ ID NO:19 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25 (or SEQ ID NO:25 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:26 (or SEQ ID NO:26 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:27 (or SEQ ID NO:27 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:33 (or SEQ ID NO:33 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:34 (or SEQ ID NO:34 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:35 (or SEQ ID NO:35 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:41 (or SEQ ID NO:41 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:42 (or SEQ ID NO:42 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:43 (or SEQ ID NO:43 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (vii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions);   (viii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:473 (or SEQ ID NO:473 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:474 (or SEQ ID NO:474 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:475 (or SEQ ID NO:475 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:481 (or SEQ ID NO:481 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:482 (or SEQ ID NO:482 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:483 (or SEQ ID NO:483 with one, two, or three amino acid additions, deletions, or substitutions);   (ix) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (x) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         99 - 101 . (canceled) 
     
     
         102 . A composition comprising a cell engager, a cell comprising a chimeric antigen receptor, or an ADC, wherein said cell engager, said chimeric antigen receptor, and said ADC comprises:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1 (or SEQ ID NO:1 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:2 (or SEQ ID NO:2 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:3 (or SEQ ID NO:3 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9 (or SEQ ID NO:9 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:10 (or SEQ ID NO:10 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:11 (or SEQ ID NO:11 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17 (or SEQ ID NO:17 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:18 (or SEQ ID NO:18 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:19 (or SEQ ID NO:19 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25 (or SEQ ID NO:25 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:26 (or SEQ ID NO:26 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:27 (or SEQ ID NO:27 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:33 (or SEQ ID NO:33 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:34 (or SEQ ID NO:34 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:35 (or SEQ ID NO:35 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:41 (or SEQ ID NO:41 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:42 (or SEQ ID NO:42 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:43 (or SEQ ID NO:43 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (vii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions);   (viii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:473 (or SEQ ID NO:473 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:474 (or SEQ ID NO:474 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:475 (or SEQ ID NO:475 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:481 (or SEQ ID NO:481 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:482 (or SEQ ID NO:482 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:483 (or SEQ ID NO:483 with one, two, or three amino acid additions, deletions, or substitutions);   (ix) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (x) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         103 - 104 . (canceled) 
     
     
         105 . The composition of  claim 102 , wherein said composition comprises a checkpoint inhibitor. 
     
     
         106 . The composition of  claim 105 , wherein said checkpoint inhibitor is selected from the group consisting of cemiplimab, nivolumab, pembrolizumab, JTX-4014, spartalizumab, camrelizumab, sintilimab, tislelizumab, toripalimab, dostarlimab, INCMGA00012, AMP-224, AMP-514, avelumab, durvalumab, atezolizumab, KN035, CK-301, AUNP12, CA-170, BMS-986189, and ipilimumab. 
     
     
         107 . A method of treating a mammal having cancer, wherein said method comprises administering, to said mammal, a composition of  claim 98 or claim 102 . 
     
     
         108 - 111 . (canceled) 
     
     
         112 . A method of treating a mammal having cancer, wherein said method comprises:
 (a) administering, to said mammal, said composition of  claim 98 or claim 102 , and   (b) administering, to said mammal, a composition comprising a checkpoint inhibitor.   
     
     
         113 - 117 . (canceled) 
     
     
         118 . A method for binding a binding molecule to a CD276 polypeptide, wherein said method comprises contacting said CD276 polypeptide with an antibody, an antigen binding fragment, or an antibody domain comprising:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1 (or SEQ ID NO:1 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:2 (or SEQ ID NO:2 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:3 (or SEQ ID NO:3 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9 (or SEQ ID NO:9 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:10 (or SEQ ID NO:10 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:11 (or SEQ ID NO:11 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17 (or SEQ ID NO:17 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:18 (or SEQ ID NO:18 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:19 (or SEQ ID NO:19 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25 (or SEQ ID NO:25 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:26 (or SEQ ID NO:26 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:27 (or SEQ ID NO:27 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:33 (or SEQ ID NO:33 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:34 (or SEQ ID NO:34 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:35 (or SEQ ID NO:35 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:41 (or SEQ ID NO:41 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:42 (or SEQ ID NO:42 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:43 (or SEQ ID NO:43 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (vii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions);   (viii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:473 (or SEQ ID NO:473 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:474 (or SEQ ID NO:474 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:475 (or SEQ ID NO:475 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:481 (or SEQ ID NO:481 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:482 (or SEQ ID NO:482 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:483 (or SEQ ID NO:483 with one, two, or three amino acid additions, deletions, or substitutions);   (ix) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (x) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         119 - 122 . (canceled) 
     
     
         123 . A method for binding a binding molecule to a CD276 polypeptide, wherein said method comprises contacting said CD276 polypeptide with a chimeric antigen receptor, a cell engager, or an ADC comprising:
 (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1 (or SEQ ID NO:1 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:2 (or SEQ ID NO:2 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:3 (or SEQ ID NO:3 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9 (or SEQ ID NO:9 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:10 (or SEQ ID NO:10 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:11 (or SEQ ID NO:11 with one, two, or three amino acid additions, deletions, or substitutions);   (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17 (or SEQ ID NO:17 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:18 (or SEQ ID NO:18 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:19 (or SEQ ID NO:19 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25 (or SEQ ID NO:25 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:26 (or SEQ ID NO:26 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:27 (or SEQ ID NO:27 with one, two, or three amino acid additions, deletions, or substitutions);   (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:33 (or SEQ ID NO:33 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:34 (or SEQ ID NO:34 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:35 (or SEQ ID NO:35 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:41 (or SEQ ID NO:41 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:42 (or SEQ ID NO:42 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:43 (or SEQ ID NO:43 with one, two, or three amino acid additions, deletions, or substitutions);   (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:49 (or SEQ ID NO:49 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:50 (or SEQ ID NO:50 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:51 (or SEQ ID NO:51 with one, two, or three amino acid additions, deletions, or substitutions);   (v) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:57 (or SEQ ID NO:57 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:58 (or SEQ ID NO:58 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:59 (or SEQ ID NO:59 with one, two, or three amino acid additions, deletions, or substitutions);   (vi) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:65 (or SEQ ID NO:65 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:66 (or SEQ ID NO:66 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:67 (or SEQ ID NO:67 with one, two, or three amino acid additions, deletions, or substitutions);   (vii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73 (or SEQ ID NO:73 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:74 (or SEQ ID NO:74 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:75 (or SEQ ID NO:75 with one, two, or three amino acid additions, deletions, or substitutions);   (viii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:473 (or SEQ ID NO:473 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:474 (or SEQ ID NO:474 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:475 (or SEQ ID NO:475 with one, two, or three amino acid additions, deletions, or substitutions), and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:481 (or SEQ ID NO:481 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:482 (or SEQ ID NO:482 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:483 (or SEQ ID NO:483 with one, two, or three amino acid additions, deletions, or substitutions);   (ix) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:529 (or SEQ ID NO:529 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:530 (or SEQ ID NO:530 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:531 (or SEQ ID NO:531 with one, two, or three amino acid additions, deletions, or substitutions); or   (x) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:537 (or SEQ ID NO:537 with one, two, or three amino acid additions, deletions, or substitutions), SEQ ID NO:538 (or SEQ ID NO:538 with one, two, or three amino acid additions, deletions, or substitutions), and SEQ ID NO:539 (or SEQ ID NO:539 with one, two, or three amino acid additions, deletions, or substitutions).   
     
     
         124 . (canceled) 
     
     
         125 . The method of  claim 123 , wherein said contacting is performed in vivo. 
     
     
         126 - 127 . (canceled)

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