Composition

Abstract

The present invention provides an antimicrobial composition comprising: (i) one or more water soluble organosilanes at a concentration of about 0.01% to about 0.4% w/v; (ii) one or more quarternary ammonium compounds at a concentration of about 0.01% to 0.5% w/v; and (iii) one or more non-ionic or amphoteric or sarcosine anionic surfactants at a concentration of about 0.05% to about 1% w/v. Methods of making the composition and methods of treating and/or preventing a skin and/or wound infection using the composition are also provided.

1 . An antimicrobial composition comprising:
 (i) one or more water soluble organosilanes at a concentration of about 0.01% to about 0.4% w/v;   (ii) one or more quarternary ammonium compounds at a concentration of about 0.01% to 0.5% w/v; and   (iii) one or more non-ionic or amphoteric or sarcosine anionic surfactants at a concentration of about 0.05% to about 1% w/v.   
     
     
         2 . The antimicrobial composition according to  claim 1 , wherein the water soluble organosilane is a quarternary ammonium silane. 
     
     
         3 . The antimicrobial composition according to  claim 2 , wherein the quaternary ammonium silane is one or more of dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride and 3-(trihydroxysilyl)propyldimethyloctadecylammoniumchloride. 
     
     
         4 . The antimicrobial composition according to  claim 1 , wherein the quaternary ammonium compound is selected from one or more of benzalkonium chloride (BAC), didecyldimethylammonium chloride (DDAC), benzethonium chloride, tetradonium bromide, cetrimonium bromide, laurtrimonium bromide, cetalkonium chloride and cetrimonium chloride. 
     
     
         5 . The antimicrobial composition according to  claim 1 , wherein the non-ionic or amphoteric or sarcosine anionic surfactant is selected from one or more of Cocomidopropyl betaine, Polyethyleneglycol lauryl ether, Poloxamer 188, Polysorbate 80, PEG-7 Glyceryl Cocoate, PEG-7 oleamide, 2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol, Polysorbate 20, Poloxamer 407, Cocomidopropylamine oxide and lauramidopropyl betaine. 
     
     
         6 . The antimicrobial composition according to  claim 1 , wherein the composition additionally comprises a chelating agent. 
     
     
         7 . The antimicrobial composition according to  claim 6 , wherein the chelating agent concentration is from about 0.01% to about 0.2% w/v. 
     
     
         8 . The antimicrobial composition according to  claim 6 , wherein the chelating agent is selected from one or more of disodium EDTA, Trisodium EDTA and tetrasodium EDTA. 
     
     
         9 . The antimicrobial composition according to  claim 1 , wherein the composition additionally comprises a polymeric biguanide. 
     
     
         10 . The antimicrobial composition according to  claim 9 , wherein the polymeric biguanide is selected from one or more of chlorhexidine and polyhexamethylene biguanide. 
     
     
         11 . The antimicrobial composition according to  claim 1 , wherein the composition has a pH of about 4.5 to about 8.5. 
     
     
         12 . The antimicrobial composition according to  claim 1 , wherein the composition further comprises one or more pharmaceutically acceptable carriers and/or excipients. 
     
     
         13 . The antimicrobial composition according to  claim 1 , wherein the composition is formulated for topical administration. 
     
     
         14 . The antimicrobial composition according to  claim 1 , wherein the composition is antibacterial. 
     
     
         15 . The antimicrobial composition according to  claim 1 , wherein the composition is anti-biofilm. 
     
     
         16 . A method of making the antimicrobial composition according to  claim 1 , the method comprising:
 (a) combining:
 (i) a water soluble organosilane at a concentration of about 0.01% to about 0.4% w/v; 
 (ii) one or more quarternary ammonium compounds at concentration of about 0.01% to 0.5% w/v; 
 (iii) a non-ionic or amphoteric surfactant at a concentration of about 0.05% to about 1% w/v; and 
 (iv) water to form a solution; and 
   (b) adjusting the pH of the solution to about 4.5 to about 8.5.   
     
     
         17 .- 22 . (canceled) 
     
     
         23 . A method of treating and/or preventing a skin and/or wound infection on a patient, the method comprising administering the antimicrobial composition according to  claim 1  to the skin and/or to the wound of the patient. 
     
     
         24 . The method according to  claim 23 , wherein the infection is a bacterial infection. 
     
     
         25 . The method according to  claim 24 , wherein the bacterial infection comprises a biofilm. 
     
     
         26 . The method according to  claim 23 , wherein the wound is an open wound. 
     
     
         27 . The method according to  claim 23 , wherein the wound is acute or chronic.