Multibiotic supplements

Abstract

Described herein are multi-biotic supplements containing a mixture of postbiotics, prebiotics, and probiotics within nested capsules, for use in supporting the health of a subject, including gut health, digestive health, and immune health.

1 . A multi-biotic supplement comprising a postbiotic or postbiotic precursor, a probiotic blend; and/or a prebiotic blend. 
     
     
         2 . The multi-biotic supplement of  claim 1 , wherein the supplement comprises a first capsule and a second capsule. 
     
     
         3 . The multi-biotic supplement of  claim 2 , wherein
 a) the first capsule comprises the postbiotic or postbiotic precursor; and   b) the second capsule comprises the probiotic blend and the prebiotic blend.   
     
     
         4 . The multi-biotic supplement of  claim 2 , wherein the second capsule is disposed within the first capsule. 
     
     
         5 . The multi-biotic supplement of  claim 1 , wherein the postbiotic or postbiotic precursor is in a solution, and wherein the solution comprises an oil. 
     
     
         6 . (canceled) 
     
     
         7 . The multi-biotic supplement of  claim 5 , wherein the oil is a medium-chain triglyceride (MCT) oil, or a coconut MCT oil. 
     
     
         8 . (canceled) 
     
     
         9 . The multi-biotic supplement of  claim 1 , wherein the supplement is essentially free of ingredients derived from animals. 
     
     
         10 . (canceled) 
     
     
         11 . The multi-biotic supplement of  claim 1 , wherein the postbiotic is a postbiotic precursor. 
     
     
         12 . The multi-biotic supplement of  claim 1 , wherein the postbiotic precursor comprises tributyrin. 
     
     
         13 . The multi-biotic supplement of  claim 1 , wherein the postbiotic precursor comprises about 300 mg of tributyrin, or about 350 mg of tributyrin. 
     
     
         14 . (canceled) 
     
     
         15 . The multi-biotic supplement of  claim 1 , wherein the probiotic blend comprises  Lactobacillus rhamnosus  GG and  Bifidobacterium animalis  ssp.  lactis.    
     
     
         16 . The multi-biotic supplement of  claim 1 , wherein the probiotic blend comprises at least 2 billion CFU of bacteria, or at least 11 billion CFU of bacteria. 
     
     
         17 . (canceled) 
     
     
         18 . The multi-biotic supplement of  claim 1 , wherein the prebiotic blend comprises LHO1-Myoviridae, LL5-Siphoviridae, T4D-Myoviridae, and LL12-Myoviridae. 
     
     
         19 . The multi-biotic supplement of  claim 1 , wherein the prebiotic blend comprises about 15 mg of bacteriophage. 
     
     
         20 . The multi-biotic supplement of  claim 2 , wherein the first capsule is a delayed release capsule. 
     
     
         21 . The multi-biotic supplement of  claim 20 , wherein the delayed release capsule comprises hypromellose and gellan gum. 
     
     
         22 . The multi-biotic supplement of  claim 2 , wherein the second capsule is an immediate release capsule. 
     
     
         23 . The multi-biotic supplement of  claim 22 , wherein the immediate release capsule comprises hypromellose. 
     
     
         24 . The multi-biotic supplement of  1 , further comprising hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate, silicon dioxide, or combinations thereof. 
     
     
         25 . The multi-biotic supplement of  claim 2 , wherein the first capsule is configured to bypass the stomach of a subject, and/or the first capsule releases its contents after entering an intestine of a user. 
     
     
         26 . (canceled) 
     
     
         27 . The multi-biotic supplement of  claim 2 , wherein the second capsule is configured to bypass the stomach and small intestine of a subject, and/or the second capsule releases its contents after entering the colon. 
     
     
         28 . (canceled) 
     
     
         29 . The multi-biotic supplement of  claim 2 , wherein the first capsule comprises tributyrin and the second capsule comprises the probiotic blend and the prebiotic blend; and
 a) the weight ratio of the tributyrin to the prebiotic blend is about 20:1; and   b) the weight ratio of the probiotic blend to the prebiotic blend is about 8:1.   
     
     
         30 . The multi-biotic supplement of  claim 29 , wherein the first capsule comprises about 300 mg of tributyrin and wherein the second capsule comprises about 120 mg of the probiotic blend and about 15 mg of the prebiotic blend. 
     
     
         31 . The multi-biotic supplement of  claim 30 , wherein the 120 mg of the probiotic blend comprises about 11 billion CFU. 
     
     
         32 . A method for improving health in a subject, comprising administering the multi-biotic supplement of  claim 1  to the subject. 
     
     
         33 . A method for improving and/or supporting one or more of gut health, digestive health, and immune health in a subject, comprising administering the multi-biotic supplement of  claim 1 . 
     
     
         34 . A kit comprising a bottle with a removable lid, wherein the bottle contains a scented insert and at least one multi-biotic supplement of  claim 1 . 
     
     
         35 . The kit of  claim 34 , wherein the bottle is glass or plastic. 
     
     
         36 . (canceled) 
     
     
         37 . The kit of  claim 34 , wherein the bottle comprises a desiccant disposed therein, and/or a layer of desiccant is affixed to an interior surface of the bottle. 
     
     
         38 . (canceled) 
     
     
         39 . The kit of  claim 37 , wherein the desiccant comprises molecular sieves, and wherein the ratio of the container size (cm 3 ) to desiccant (g) is about 130 to 6. 
     
     
         40 . (canceled) 
     
     
         41 . The kit of  claim 34 , wherein (i) the bottle is opaque, (ii) the scented insert comprises one or more markings, and/or (iii) the bottle comprises one or more markings. 
     
     
         42 .- 44 . (canceled) 
     
     
         45 . The kit of  claim 34 , wherein the scented insert comprises a plant oil or at least one compound derived from plants, optionally wherein the scented insert comprises peppermint oil or a citrus oil. 
     
     
         46 .- 50 . (canceled)