Nicotine Oral Delivery Composition

Abstract

A nicotine oral delivery composition includes a source of nicotine and a proflavour compound, wherein the proflavour compound includes a flavour component and a support component joined by an enzymatically cleavable bond, wherein the nicotine oral delivery compound is in solid form, and wherein the enzymatically cleavable bond is not a glycosidic bond.

1 . A nicotine oral delivery composition comprising a source of nicotine and a proflavour compound, wherein the proflavour compound comprises a flavour component and a support component joined by an enzymatically cleavable bond, wherein the nicotine oral delivery composition is in solid form, and wherein the enzymatically cleavable bond is not a glycosidic bond. 
     
     
         2 . The nicotine oral delivery composition according to  claim 1 , wherein the enzymatically cleavable bond is cleaved by reaction with an enzyme present in saliva, wherein the enzymatically cleavable bond is an ester bond, an amine bond or an anhydride bond. 
     
     
         3 . The nicotine oral delivery composition according to  claim 1 , wherein the proflavour compound is an ester compound, an amide compound, an anhydride compound or a combination thereof. 
     
     
         4 . The nicotine oral delivery composition according to  claim 3 , wherein the proflavour compound is an ester compound. 
     
     
         5 . The nicotine oral delivery composition according to  claim 4 , wherein the ester compound is one or more of a glycerol ester, a propylene glycol ester, a cholesterol ester, a choline ester, a glyceric acid ester (or glycerate), a carboxylic cholesterol ester, a lactic acid ester, a diglyceride and a triglyceride. 
     
     
         6 . The nicotine oral delivery composition according to  claim 4 , wherein the ester compound is formed by reaction of an alcohol and a carboxylic acid, wherein either the flavour component or the support component is derived from the alcohol and the other of the flavour component and the support component is derived from the carboxylic acid. 
     
     
         7 . The nicotine oral delivery composition according to according to  claim 6 , wherein the flavour component is derived from the carboxylic acid and the support component is derived from the alcohol. 
     
     
         8 . The nicotine oral delivery composition according to according to  claim 7 , wherein the carboxylic acid is selected from ascorbic acid, citric acid, malic acid, oxalic acid, lactic acid, butyric acid, caproic acid, caprylic acid and lauric acid, and/or wherein the alcohol is selected from glycerol, propylene glycol, cholesterol and/or choline. 
     
     
         9 . The nicotine oral delivery composition according to  claim 6 , wherein the flavour component is derived from the alcohol and the support component is derived from the carboxylic acid. 
     
     
         10 . The nicotine oral delivery composition according to  claim 9 , wherein the alcohol is selected from citronellol, geraniol, farnesol, phenylhexanol, borneol, polysantol, (Z)-3-hexenol, phenethylol, dimethyl benzyl carbinol and menthol, α-ionol, β-ionol or 3-hydroxy-β-ionol and/or wherein the carboxylic acid is selected from glyceric acid, carboxylic cholesterol and lactic acid. 
     
     
         11 . The nicotine oral delivery composition according to  claim 1 , wherein the source of nicotine is selected from the group consisting of nicotine salt, free-base nicotine, stabilised nicotine or a combination thereof. 
     
     
         12 . A nicotine oral delivery product comprising a pouch and a nicotine oral delivery composition according to  claim 1 , wherein the pouch is water-insoluble and is permeable for saliva and wherein the nicotine oral delivery composition is contained within the pouch. 
     
     
         13 . A method of making the nicotine oral delivery product according to  claim 12 , the method comprising enclosing the nicotine oral delivery composition according to  claim 1  in the pouch and sealing the pouch. 
     
     
         15 . A method for oral delivery of nicotine, the method comprising placing the nicotine oral delivery product according to  claim 12  into a user's mouth.