Implantation device

Abstract

Provided is a novel device or a novel implantation device. The implantation device is one of the following: (1) an implantation device comprising a material (A) having a density of 12 mg/cm3 or more and a dissolution rate of 80% or less as determined after immersion of the material (A) in physiological saline at 37° C. for 24 hours; and (2) an implantation device comprising a material (A) having a dissolution rate of 80% or less as determined after immersion of the material (A) in physiological saline at 37° C. for 24 hours and a ratio of X/Y of 0.24 or more wherein X is a density (mg/cm3) of the material (A) and Y is a degree of swelling of the material (A) expressed in terms of fold increase as determined after immersion of the material (A) in physiological saline at 37° C. for 60 minutes.

1 . An implantation device comprising a material (A) having a density of 12 mg/cm 3  or more and a dissolution rate of 80% by mass or less as determined after immersion of the material (A) in physiological saline at 37° C. for 24 hours. 
     
     
         2 . An implantation device comprising a material (A) having a dissolution rate of 80% or less as determined after immersion of the material (A) in physiological saline at 37° C. for 24 hours and a ratio of X/Y of 0.22 or more wherein X is a density (mg/cm 3 ) of the material (A) and Y is a degree of swelling of the material (A) expressed in terms of fold increase calculated on mass basis after immersion of the material (A) in physiological saline at 37° C. for 60 minutes. 
     
     
         3 . The device according to  claim 1 , wherein the material (A) has a ratio of X/Y of 0.22 or more wherein X is a density (mg/cm 3 ) of the material (A) and Y is a degree of swelling of the material (A) expressed in terms of fold increase calculated on mass basis after immersion of the material (A) in physiological saline at 37° C. for 60 minutes. 
     
     
         4 . The device according to  claim 1 , wherein the material (A) has a dissolution rate of 60% by mass or less as determined after immersion of the material (A) in physiological saline at 37° C. for 24 hours. 
     
     
         5 . The device according to  claim 1 , wherein the material (A) has a degree of swelling of 70-fold or less calculated on mass basis after immersion of the material (A) in physiological saline at 37° C. for 60 minutes. 
     
     
         6 . The device according to  claim 1 , wherein the material (A) has a ratio of X/Y of 0.23 or more wherein X is a density (mg/cm 3 ) of the material (A) and Y is a degree of swelling of the material (A) expressed in terms of fold increase calculated on mass basis after immersion of the material (A) in physiological saline at 37° C. for 60 minutes. 
     
     
         7 . The device according to  claim 1 , wherein the material (A) has a density of 14 mg/cm 3  or more, a dissolution rate of 3 to 50% by mass as determined after immersion of the material (A) in physiological saline at 37° C. for 24 hours and a ratio of X/Y of 0.23 or more wherein X is a density (mg/cm 3 ) of the material (A) and Y is a degree of swelling of the material (A) expressed in terms of fold increase calculated on mass basis after immersion of the material (A) in physiological saline at 37° C. for 60 minutes. 
     
     
         8 . The device according to  claim 1 , wherein the material (A) contains a bioabsorbable material (A1). 
     
     
         9 . The device according to  claim 1 , wherein the material (A) contains a gelatin. 
     
     
         10 . The device according to  claim 1 , wherein the material (A) forms at least part of a surface of the device. 
     
     
         11 . The device according to  claim 1 , further comprising a non-bioabsorbable material (B). 
     
     
         12 . The device according to  claim 11 , wherein the material (A) contains a bioabsorbable material (A1), and the material (A) is integrated with the non-bioabsorbable material (B). 
     
     
         13 . The device according to  claim 11 , wherein the material (A) contains a bioabsorbable material (A1), and the non-bioabsorbable material (B) is contained in an amount of 1 part by volume or more relative to 100 parts by volume of the material (A). 
     
     
         14 . The device according to  claim 12 , wherein the non-bioabsorbable material (B) is contained in an amount of 10 parts by volume or more relative to 100 parts by volume of the material (A), and wherein the material (A) forms at least part of a surface of the device. 
     
     
         15 . The device according to  claim 11 , wherein the non-bioabsorbable material (B) has an adhesion preventive ability. 
     
     
         16 . The device according to  claim 1 , wherein the device is substantially free of growth factors. 
     
     
         17 - 22 . (canceled) 
     
     
         23 . A method for implanting the device according to  claim 1 , comprising implanting the device into an implantation site. 
     
     
         24 . A method for activating an implantation site, comprising implanting the device according to  claim 1  into the implantation site. 
     
     
         25 . The method according to  claim 23 , wherein material (A) contains a bioabsorbable material (A1), and the bioabsorbable material (A1) is biologically absorbed. 
     
     
         26 . The method according to  claim 23 , wherein material (A) contains a bioabsorbable material (A1) to allow formation of an encapsulating membrane at the implantation site. 
     
     
         27 . A method comprising implanting the device according to  claim 1  into an implantation site, wherein the device comprises a non-bioabsorbable member as a material (A) or comprises a non-bioabsorbable material (B), and retrieving the non-bioabsorbable material after implantation of the device. 
     
     
         28 . The method according to  claim 27 , wherein the retrieval is performed without causing bleeding, inflammation and/or rupture of a blood vessel. 
     
     
         29 . An implantation method comprising implanting a cell- or tissue-containing device into a site in which the device according to  claim 1  has been implanted. 
     
     
         30 . A method for treating a disease or a symptom, comprising implanting a cell- or tissue-containing device into a site in which the device according to  claim 1  has been implanted. 
     
     
         31 . The method according to  claim 29 , further comprising implanting the device according to  claim 1 . 
     
     
         32 . The device or method according to  claim 23 , wherein the implantation site is a subcutaneous site. 
     
     
         33 . A method for forming an encapsulating membrane, the method comprising implanting the device according to  claim 1  into an implantation site. 
     
     
         34 . The method according to  claim 23 , wherein the implantation site is an implantation site of a cell- or tissue-containing device. 
     
     
         35 . The method according to  34 , wherein the device is in combination with a cell- or tissue-containing device. 
     
     
         36 . The method according to  claim 34 , wherein the cell- or tissue-containing device has an immunoisolation layer containing a polyvinyl alcohol resin (A). 
     
     
         37 . The method according to  34 , wherein the cell- or tissue-containing device comprises an immunoisolation layer containing at least one or more polyvinyl alcohol resins (A) selected from a modified polyvinyl alcohol resin having an active carbonyl group (A1), a polyvinyl alcohol resin having a triad syndiotacticity of 32 to 40% (A2), and a polyvinyl alcohol resin having a degree of saponification of 97 mol % or more (A3). 
     
     
         38 . The method according to  claim 34 , wherein the cell or tissue contains at least one selected from a pancreatic islet, hepatocytes, stem cells that give rise to islet cells or hepatocytes, and progenitor cells that give rise to islet cells or hepatocytes.